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Photocatalytic Approach Produces New Drug Candidates

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PRINCETON, N.J., June 25, 2014 — Light and nickel share a unique bond as chemical catalysts for potential new drugs. Princeton University chemists studying photoredox catalysis and nickel catalysis have discovered that bringing the two processes together enables reactions that neither could produce on its own. Pairing photoredox and nickel catalysts bonded multiple traditionally unreactive coupling partners, the researchers said. Specifically, the photoredox catalyst — which is activated by LEDs or other lights — transforms common carboxylic acids in a molecule into reactive sites. The nickel catalyst...Read full article

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    Published: June 2014
    AmericasBasic SciencecarboncatalysischemicalsEli LillyenergyLight SourcesMerckmoleculesNational Institute of General Medical SciencesNew JerseynickelOpticsPrinceton UniversityResearch & TechnologyRocheFrick Chemistry Labphotoredoxcoupling partnersDavid MacMillanJames S. McDonnell Distinguished University ProfessorAbigail Doylecarboxylic acidAmgenShanghai Institute of Organic ChemistryLEDs

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