A new molecular probe, based on the fluorescence in situ hybridization (FISH) technique, uses compact quantum dots (QDs) instead of fluorescent dyes to illuminate molecules and diseased cells. Developed by a team from the University of Illinois at Urbana-Champaign and the Mayo Clinic, the QDs provide greater stability and accuracy compared with dyes. Quantum dots illuminate the locations of individual mRNA as red dots in the cytoplasm of a single HeLa cell. The blue region is the nucleus. This work was a collaborative effort between Illinois Bioengineering and Mayo Clinic researchers....Read full articleRelated content from Photonics MediaARTICLESThree-Photon Microscopy Reveals Immune Cell Behavior in Real TimeA research group from Cornell University has used three-photon microscopy to image the full depth of the popliteal lymph node in a living mouse — reportedly for the first time. The researchers...BioPhotonics May/Jun 2022 IssuePolymer Molecules Fluoresce After Chemical AdjustmentsETH Zurich researchers have introduced a method that relies on chemical adjustments occurring in fluorescent organic polymer molecules to generate a broad palette of color. The approach is an...Photonics Spectra June 2021 IssuePortable Laser-Based Scanning Device Detects Critical BiomarkersResearchers at the University of Arkansas for Medical Sciences (UAMS) reported advancements to the previously developed Cytophone device. In the current work, the researchers integrated a miniature...BioPhotonics Nov/Dec 2022 IssueTechnique Enables In Vivo Vascular Imaging at Single-Cell ResolutionA two-photon fluorescence imaging method developed by researchers at the University of Hong Kong and the University of California, Berkeley was able to image the flow of individual blood cells at...BioPhotonics Nov/Dec 2022 IssuePRODUCTSIR MicroscopeThe Nicolet RaptIR FTIR Microscope from Thermo Fisher Scientific Corp. is a Fourier Transform Infrared (FTIR) device that produces high-quality visual images for the drug discovery, design, and...Photonics Spectra May 2022 IssueCell SorterThe FACSDiscover™ S8 Cell Sorter from Becton, Dickinson and Co. features CellView™ image technology, combining spectral flow cytometry with sort-capable imaging. The system is...BioPhotonics Sep/Oct 2022 IssueAI MicroscopeThe APEXVIEW™ APX100 All-in-One Microscope from Evident Corp. provides publication-quality images for life science research. Featuring Olympus optics, intuitive software, artificial...BioPhotonics Sep/Oct 2022 IssueMicroscope CameraThe LC35 microscope camera from Olympus Corp. provides quality brightfield images in a cost-effective package. With a 3.5-MP CMOS sensor and versatile exposure times and resolution modes, the...Photonics Showcase April 2022 IssuePHOTONICS HANDBOOK ARTICLESFluorescence Lifetime Imaging: Choosing the Best Approach: Fluorescence lifetime imaging microscopy (FLIM), which measures the spatial distribution of the fluorescence decay, can be achieved either in the time or in the frequency domain. Each approach exhibits advantages and disadvantages, depending on the type of light detector and acquisition method employed.The term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookSuperresolution Microscopy: An Imaging Revolution: Despite tremendous accomplishments in recent years, superresolution microscopy is a relatively young field, and confusion exists in this domain of many abbreviations. However, this makes for captivating times as superresolution microscopy opens the door to wider imaging applications.Superresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookMachine Vision Cameras: Making the Right Selection: Improvements and affordability have broadened the use of vision systems for inspection, but several factors should be considered before making a purchase.Technological advances have resulted in new, higher-quality sensors that enable machine vision cameras to deliver greater features and functionality at a lower cost than ever before. These factors...Photonics HandbookAspheric Lenses: Design Considerations: This first of two articles will cover design and manufacturing options for aspheres; the second will include more detail on manufacturing and testing processes. These articles will provide the tools optics designers need to tailor their designs to the appropriate manufacturing process and to optimize the cost of component fabrication.Aspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookWHITEPAPERSHow Right Angle Prisms Work?How Right Angle Prisms Work? Mainly used in various optical instruments and optical imaging fields, for bending image paths or 90° turning rays. Right-angle prisms can produce left-handed images that...Photonics.com 11/1/2022Precision Motion and How to Achieve ItNanoscale motion requires fastidious attention to instrumentation, passive controls, and experiment design. Most users have experience in motion control within the sphere of the microscale. In this...Photonics.com 9/1/2022Confocal Raman and Photoluminescence Microscopy for Forensic InvestigationsForensic investigations often study extremely small samples which may need analyses by multiple techniques. Confocal Raman and Photoluminescence (PL) Microscopy are well-suited techniques for dealing...Photonics.com 7/29/2022Embedded Motion Speeds Development of Next-Gen Sequencing InstrumentsSmall, precise motion modules enhance NGS system design and performance. Following the Human Genome Project, companies are racing to develop Next-Gen Sequencing (NGS) instruments for DNA sequencing....Photonics.com 12/14/2022WEBINARSThe Future of Imaging: Three PerspectivesPresenters: Professor Stephen Boppart The Future of Healthcare With Optical Biomedical Imaging A medical doctor and professor at the University of Illinois, Boppart's...Photonics.com 12/14/2011KEYNOTE: Specialized Laser Probes Capture Fluorescence Detail and Drive DiagnosticsArrigoni discusses the various applications of lasers to biology and medicine, and categorizes them by the type of process involved and the most significant trends: Fluorescence (spectral) imaging by...Photonics.com 10/27/2022Cellular Bioluminescence Imaging of Circadian ClocksJoin Us for a Free Webinar on Cellular Bioluminescence Imaging of Circadian Clocks With David K. Welsh, M.D. and Colin Coates Bioluminescence imaging of live cells has recently been recognized...Photonics.com 4/26/2016BioPhotonics Conference: October 26 - 28The publishers of BioPhotonics invite you to attend a free virtual conference spanning three days. The BioPhotonics Conference will feature insights and innovations in microscopy, spectroscopy, flow...Photonics.com 10/26/2021PHOTONICS DICTIONARY TERMSnative fluorescenceThe light emitted from tissues without the use of fluorescent dyes as markers. Because cancerous tissues and normal tissues have differing emission spectra, the native fluorescence can be used to...EDU.photonics.com 9/8/2009Digital Imaging and Communications in MedicineDigital Imaging and Communications in Medicine (DICOM) is an international standard for medical imaging created by both the National Electrical Manufacturers Association (NEMA) and the American...EDU.photonics.com 1/26/2017quantum dotsAlso known as QDs. Nanocrystals of semiconductor materials that fluoresce when excited by external light sources, primarily in narrow visible and near-infrared regions; they are commonly used as...EDU.photonics.com 6/30/2017induced pluripotent stem cellsInduced pluripotent stem (iPS) cells are ordinary cells that are genetically reprogrammed to an embryonic stem cell-like state to allow the human cells to be used for therapeutic purposes....EDU.photonics.com 3/5/2018MEDIALight Matters Extra: Taking Photonics Innovations from the Lab to the Operating Room - 01.2018In this month's Light Matters Extra, we give you an in-depth look at the relationship between researchers and scientists at the University of California Davis, and surgeons and clinicians at nearby...Photonics.com 1/18/2018Supporting the Photonics Industry from the Laboratory - LIGHT MATTERS 01.2018On this month's episode of Light Matters, we take you to central Massachusetts as Worcester Polytechnic Institute and Quinsigamond Community College take on a comprehensive joint photonics laboratory...Photonics.com 1/18/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 2/21/2018Light Tomorrow with TodayLuminate NY, the only optics, photonics and imaging (OPI) accelerator and investment fund in the world, announced the final winners at the Light Tomorrow with Today event in Rochester, NY. For the...Photonics.com 7/2/2018PHOTONICS BUYERS' GUIDE CATEGORIESFluorescent DyesMedical/Biomedical MicroscopesVideo MicroscopesBioluminescence MicroscopesCOMPANIESLaCroix Precision OpticsOptics that Defend, Build, Cure and Discover The LaCroix name is synonymous with quality precision optics. Since 1947, three generations of family leadership have placed LaCroix Precision Optics...Photonics Buyers' GuideOmega Optical LLCOmega Optical has been bringing you the light you need since 1969. Omega specializes in thin-film interference filters in the 190 nm - 10 µm wavelength range. The layers are...Photonics Buyers' GuidePrior Scientific Inc.For over 100 years, Prior Scientific has been manufacturing precision optical and electro-mechanical equipment and instrumentation. Prior is a leader in the development of precision motion,...Photonics Buyers' GuideAndor TechnologyWe are global leaders in the development and manufacture of high performance scientific digital cameras for academic, industrial and government applications. Through continuous dialogue with our...Photonics Buyers' Guide