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Deposition Sciences Inc. - Difficult Coatings - LB - 8/23

Raman Spectroscopy Analysis of Polymorphs

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Polymorph identification is important for the pharmaceutical industry, and Raman spectroscopy can provide a simple way to perform this analysis.

Dr. Robert Alexander, PerkinElmer Ltd.

Some molecules with the same chemical formula can have different crystal structure forms — called polymorphs. There are two ways in which crystal structures can arise: arrangement (or packing) polymorphism and conformational polymorphism. Pseudopolymorphs are crystalline structures that also incorporate solvent molecules and are, therefore, not chemically identical to the true polymorphs. The differences in the crystalline structure of polymorphs can affect a substance’s characteristics — solubility, dissolution rate, density, hardness, shape — which, in turn, can influence their important...Read full article

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    Published: April 2008
    BiophotonicsCoatingscrystal structureFeaturesmoleculespolymorphs

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