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Raman imaging of an entire living mouse

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Technique is 100 to 1000 times more sensitive than fluorescence imaging with quantum dots.

David L. Shenkenberg

Fluorescence microscopy cannot easily reveal internal details of a living animal, in part because fluorescence cannot easily penetrate through skin. Although near-infrared emission improves the penetration of fluorescence through skin, the lack of available fluorophores without substantial overlap in that region makes simultaneous imaging of multiple molecular targets a difficult endeavor. Furthermore, autofluorescence signals from skin often obfuscate the fluorescence signal. In contrast, multiple labels can be resolved easily using Raman spectroscopy, and the Raman signal can be...Read full article

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    Published: June 2008
    Glossary
    fluorescence microscopy
    Fluorescence microscopy is a specialized optical imaging technique used in biology, chemistry, and materials science to visualize and study specimens that exhibit fluorescence. Fluorescence is the phenomenon where a substance absorbs light at one wavelength and emits light at a longer wavelength. In fluorescence microscopy, fluorescent dyes or proteins are used to label specific structures or molecules within a sample. The basic principles of fluorescence microscopy involve illuminating the...
    autofluorescence signalsBiophotonicsfluorescence microscopyMicroscopymolecularResearch & Technology

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