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Single-Molecule Localization Microscopy Approach Improves Precision

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An interferometric, single-molecule localization method for superresolution fluorescence microscopy, developed by scientists at the Institute of Biophysics of the Chinese Academy of Sciences, could significantly improve localization precision compared with conventional centroid fitting methods. The new approach is called Repetitive Optical Selective Exposure (ROSE). It was developed by professors Tao Xu and Wei Ji. The ROSE technique uses six different direction and phase interference fringes to excite fluorescent molecules. The intensity of the molecules is closely related to the phase...Read full article

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    Photonics Spectra
    Nov 2019
    GLOSSARY
    fluorescence
    The emission of light or other electromagnetic radiation of longer wavelengths by a substance as a result of the absorption of some other radiation of shorter wavelengths, provided the emission continues only as long as the stimulus producing it is maintained. In other words, fluorescence is the luminescence that persists for less than about 10-8 s after excitation.
    interferometry
    The study and utilization of interference phenomena, based on the wave properties of light.
    Research & TechnologyeducationChinese Academy of SciencesAsia-Pacificimaginglight sourcesMicroscopyopticssuperresolutionBiophotonicsmedicalfluorescencenanoNanopositioningnanoscale biointerferometrysingle-molecule microscopyTech Pulse

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