An interferometric, single-molecule localization method for superresolution fluorescence microscopy, developed by scientists at the Institute of Biophysics of the Chinese Academy of Sciences, could significantly improve localization precision compared with conventional centroid fitting methods. The new approach is called Repetitive Optical Selective Exposure (ROSE). It was developed by professors Tao Xu and Wei Ji. The ROSE technique uses six different direction and phase interference fringes to excite fluorescent molecules. The intensity of the molecules is closely related to the phase...Read full articleRelated content from Photonics MediaARTICLESGhost Imaging Speeds Up Superresolution MicroscopyScientists from the Chinese Academy of Sciences have developed a new imaging technique that produces nm-scale resolution using significantly fewer images than traditional nanoscopy techniques. The...BioPhotonics Mar/Apr 2020 IssueImaging Technology Enables Superresolution Inside Whole CellsPurdue University researchers have developed a technology that enables 3D superresolution imaging inside whole-cell or tissue specimens. The technology allows scientists to locate the positions of...Photonics Spectra July 2020 IssueNew Molecule Marker Enables ‘Unprecedented’ Study of MitochondriaA team at Nagoya University’s Institute of Transformative Bio-Molecules has developed a marker molecule that bypasses the problem of photobleaching in STED microscopy. It’s allowing an...Photonics.com 10/22/2019New Technique Enhances Superresolution MicroscopyResearchers at Bielefeld University have demonstrated improvements in superresolution structured illumination microscopy (SR-SIM), demonstrating that the technique is possible in real time and at a...Photonics.com 10/22/2019PRODUCTSLED Hyperspectral LightingThe HSI range of LED hyperspectral lighting from EFFILUX SAS offers a tunable continuous spectrum from 400 to 900 nm, which can be easily integrated into a wide variety of lighting for machine vision...Photonics.com 11/27/2019Facial Recognition and Temperature Detection CameraThe Access Control Camera from Viewell Electronics Technology Co. Ltd. is a non-contact facial recognition and temperature detection camera. Users can automatically identify unmasked personnel,...Photonics.com 10/1/2020Field Emission Scanning Electron MicroscopeThe JSM-IT700HR InTouchScope field emission scanning electronic microscope from JEOL is a compact system that offers ultra-high resolution and versatile analytical capabilities. The JSM-IT700HR...Photonics.com 9/18/2020Light EngineThe ZIVA light engine from Lumencor Inc. features seven individually addressable lasers and advanced electronic control systems. The engine delivers high optical power, stability, and...Photonics Spectra February 2020 IssuePHOTONICS HANDBOOK ARTICLESNanopositioning: A Step Ahead: It is almost a cliché among students of creativity that innovation occurs at the intersection of fields. Since nanopositioning is a discipline that has enabled swiftly evolving application arenas as diverse as materials science, genomics, photonics, defense, biophysics, and semiconductors, it’s unsurprising that its pace of innovation is nothing short of blistering in recent years.By its original definition, a nanopositioning device is a mechanism capable of repeatedly delivering motion in increments as small as one nanometer. Lately demands from industry and research have...Photonics HandbookInterferometry: Measuring with Light: Long applied to optical shop testing, interferometry is now used to measure many different types of parts in a variety of applications, such as optical system performance, surface roughness, surface form, and displacement of moving surfaces.An interferometer is an instrument that compares the position or surface structure of two objects. The basic two-beam division of amplitude interferometer components consists of a light source, a...Photonics HandbookAspheric Lenses: Design Considerations: This first of two articles will cover design and manufacturing options for aspheres; the second will include more detail on manufacturing and testing processes. These articles will provide the tools optics designers need to tailor their designs to the appropriate manufacturing process and to optimize the cost of component fabrication.Aspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookLasers for Microscopy: Major Trends: In order for biologists, drug developers, clinical lab professionals and other scientists to fully exploit new microscopy techniques and applications, parallel developments in laser technology are often required. Laser manufacturers are responding with products optimized to match the needs of these applications.Laser development for the microscopy market continues to be driven by key trends in applications, which currently include superresolution techniques, multiphoton applications in optogenetics and...Photonics HandbookWHITEPAPERSExtreme Metrology: Big Science Requires a Nano-perspectiveExtreme metrology represents the cutting edge in technological demand from the material researchers, astronomers, and other physicists whose work demands nearly unattainable precision. Understanding...Photonics.com 8/19/2020Understanding Virus Mechanisms – One Particle at a TimeSingle-molecule microscopy techniques facilitate direct study of molecular mechanisms, enabling leaps in understanding surrounding how viruses assemble, disassemble, and interact with their hosts. In...Photonics.com 9/18/2020Is a DIY Microscope for you?Recently, it has become very popular for researchers to explore building their own microscopes. Budgetary and technical specifications are among the motivations for this approach. However, there is a...Photonics.com 3/5/2020Advances in Precision Motion Control and MechanismsPart I: Improving Stage Accuracy with ACS Dynamic Error Compensation Even the best precision motion systems exhibit some amount of position error. These errors can be measured using external...Photonics.com 9/5/2019WEBINARSAdvances in Rapid 3D Imaging of Large Tissue SamplesThis webinar will discuss rapid 3D, multiplexed imaging of large tissue samples, based on recent advances in light-sheet fluorescence microscopy, multiplexed molecular labeling, and optical tissue...Photonics.com 1/24/2019Techniques in Biophotonic ImagingFREE WEBINAR Sponsored by: Hamamatsu & Applied Scientific Instrumentation Additional Questions & Answers from the webinar are below: Dr. Kimani C. Toussaint Jr. Quantitative...Photonics.com 3/21/2013Computational Microscopy, Sensing and Diagnostics for Telemedicine and Global Health ApplicationsAdditional Questions and Answers from the Webinar are below: With more than 6 billion cell phone users in the world, the majority of them in developing countries, there are opportunities for...Photonics.com 6/5/2013Advances in Biomedical PhotonicsA Free Webinar: Advances in Biomedical Photonics, Thursday, July 19, at 1 p.m. EDT/10 a.m. PDT/ 5 p.m. GMT/UTC Questions & Answers from the Webinar: Lihong V. Wang, PhD Gene...Photonics.com 7/19/2012PHOTONICS DICTIONARY TERMSatom opticsThe area of optics in which the wave nature of a particle is exploited to carry out very accurate interferometry and other optical techniques with atoms instead of photons. In this process, particles...EDU.photonics.com 3/5/2018scanning coherent slope microscopyMeasures by heterodyning interferometry the local slope of a vibrating sample. The method allows the reconstruction of a three dimensional map of the surface in order to determine the slope and...EDU.photonics.com 3/5/2018piecewise interferometryAn interferometric technique for the generation of precision gratings that allows for sequential exposure of small segments in the writing of a large grating, allowing increased intensity that...EDU.photonics.com 9/8/2009nanopositioning actuatorA positioning device capable of producing repeatable motion in increments as small as 1 nm or less. Nanopositioning actuators are frictionless devices that are typically piezoelectrically driven....EDU.photonics.com 9/8/2009MEDIASupporting the Photonics Industry from the Laboratory - LIGHT MATTERS 01.2018On this month's episode of Light Matters, we take you to central Massachusetts as Worcester Polytechnic Institute and Quinsigamond Community College take on a comprehensive joint photonics laboratory...Photonics.com 1/18/2018Light Matters Extra: Taking Photonics Innovations from the Lab to the Operating Room - 01.2018In this month's Light Matters Extra, we give you an in-depth look at the relationship between researchers and scientists at the University of California Davis, and surgeons and clinicians at nearby...Photonics.com 1/18/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 2/21/2018Light Matters Extra: Weird and Strange: Quantum Photonics - 03.2018In this month's Light Matters Extra, we take you to the Quantum Photonics Laboratory at MIT run by Dr. Dirk Englund. Dr. Englund's group, the Quantum Photonics Group, is made up of postdocs and...Photonics.com 3/29/2018PHOTONICS BUYERS' GUIDE CATEGORIESMicropositionersSurface ProfilersPositioning EquipmentKrypton-Ion LasersCOMPANIESLaCroix Precision OpticsOptics that Defend, Build, Cure and Discover The LaCroix name is synonymous with quality precision optics. Since 1947, three generations of family leadership have placed LaCroix Precision Optics...Photonics Buyers' GuideOhara Corporation, Western OfficeOhara manufactures precision optical glasses: strip/slab, cut/molded blanks, pressings, high homogeneity blanks, fine gobs, polished ball lenses, near-UV transmitting i-Line glass, ceramic...Photonics Buyers' GuideSmarAct Inc.Since 2005, SmarAct develops piezo-based, high-performance positioners and measurement tools for the micro- and nanometer scale. Positioning systems with numerous degrees of freedom and parallel...Photonics Buyers' GuideMad City Labs Inc.Mad City Labs, Inc. is a leading manufacturer of piezo nanopositioning systems and instrumentation capable of sub-nanometer positioning resolution. Our product line of nanopositioners,...Photonics Buyers' Guide