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Spectroscopic Toolkit for Structural Biology Could Aid in Drug Design

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A fluorescence-based imaging technique for monitoring single molecules could lead to a better understanding of how molecules are assembled, function, and interact, aiding in structure-guided drug design. Clemson University researchers led by professor Hugo Sanabria and working with researchers from Heinrich Heine University developed a hybrid fluorescence spectroscopic toolkit to study the essential reaction steps of enzymes. By combining single-molecule and ensemble multiparameter fluorescence detection, electron paramagnetic resonance spectroscopy, and Förster resonance energy...Read full article

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