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Spectroscopy Explores Photoinduced Reactions in Anticancer Drug

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Using IR spectroscopy, researchers have gained fresh insight into how a platinum-based chemotherapy drug candidate functions when activated by light. Completely inactive and nontoxic in the dark, the treatment can be targeted to cancerous areas and is triggered only when directed light hits it, causing the compound to degrade into active platinum and releasing ligand molecules to attack cancer cells. The photodecomposition mechanism of trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary attenuated total reflection...Read full article

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