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Thirst-quenching cocktail enables noninvasive bioluminescence imaging

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Gwynne D. Koch

Bioluminescence imaging is commonly used for visualizing the regulation of gene expression in live whole animals to monitor rates of tumor growth, infection, development and circadian rhythms. Genetically engineered mice express the gene for the enzyme luciferase, which initiates a chemical reaction that emits light when exposed to the substrate luciferin. Typically, luciferin is injected into animals before they are anesthetized for imaging. However, stress caused by handling the animals and tissue damage resulting from injection can affect gene expression and change the phase of an animal’s...Read full article

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    Published: January 2007
    Glossary
    light
    Electromagnetic radiation detectable by the eye, ranging in wavelength from about 400 to 750 nm. In photonic applications light can be considered to cover the nonvisible portion of the spectrum which includes the ultraviolet and the infrared.
    bioluminescence imagingBiophotonicsenzyme luciferaselightNews & FeaturesSensors & Detectors

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