A research group from Cornell University has used three-photon microscopy to image the full depth of the popliteal lymph node in a living mouse — reportedly for the first time. The researchers successfully observed the dynamic interactions of immune cells in the lymph node in real time and at micron-scale resolution. The three-photon imaging technique for visualizing lymph nodes could provide the same level of precision for cancer biology and other biomedical research fields, according to the team. 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