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Leibniz Institute Observes Neuronal Structures with Holography

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Using a multimode optical fiber as thin as a human hair, scientists at the Leibniz-Institute of Photonic Technology have observed at high resolution the neuronal structures inside deep brain areas of living mice. The researchers drew on holographic methods for controlling light to design a fluorescence imaging system compact enough to fit on the tip of a fiber. The ultranarrow, minimally invasive probe offers a smaller footprint and higher resolution compared to endoscopes based on graded-index lenses or fiber bundles. According to the researchers, the new probe is capable of acquiring...Read full article

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    Published: November 2018
    Glossary
    optical fiber
    Optical fiber is a thin, flexible, transparent strand or filament made of glass or plastic used for transmitting light signals over long distances with minimal loss of signal quality. It serves as a medium for conveying information in the form of light pulses, typically in the realm of telecommunications, networking, and data transmission. The core of an optical fiber is the central region through which light travels. It is surrounded by a cladding layer that has a lower refractive index than...
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    adaptive optics
    Adaptive optics (AO) is a technology used to improve the performance of optical systems by reducing the effects of atmospheric distortions. The Earth's atmosphere can cause light passing through it to experience distortions, resulting in image blurring and degradation in various optical applications, such as astronomical observations, laser communications, and imaging systems. Adaptive optics systems actively adjust the optical elements in real-time to compensate for these distortions. Key...
    holography
    Holography is a technique used to capture and reconstruct three-dimensional images using the principles of interference and diffraction of light. Unlike conventional photography, which records only the intensity of light, holography records both the intensity and phase information of light waves scattered from an object. This allows the faithful reproduction of the object's three-dimensional structure, including its depth, shape, and texture. The process of holography typically involves the...
    multimode fiberResearch & TechnologyeducationEuropeLeibniz-Institute of Photonic Technologyfiber opticsoptical fiberImagingdeep neuronal imagingMicroscopyoptogeneticsBiophotonicsOpticsadaptive opticsendoscopesoptical probeholographyholographic endoscopyBioScanEuro News

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