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Using selectivity and sensitivity to detect the whole tumor

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Amanda D. Francoeur, [email protected]

Removing tumors and detecting even the most slightly diseased tissue have become easier with the help of bright GFP and a GFP-expressing adenovirus. The fluorescence labeling technique, described in a recent study, will help to target and illuminate a specific tumor, along with any scattered malignant cells found in normal tissue surrounding the growth that may otherwise be hard to identify. “The ability to selectively make tumors fluorescent will enhance the ability to detect tumors during the surgical procedure,” said Dr. Robert Hoffman, lead researcher and president of the biotechnology...Read full article

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    Published: November 2009
    Glossary
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    abnormal cellsadenovirusanticancerBiophotonicscancercolorectal cancerflorescence labelingfluorescencefluorescence endoscopyfluorescent imagingGFPGFP expressionGFP genegreen fluorescent proteinHoffmanImaginglung cancerNews & FeaturesOBP-401peritoneal lesionsProceedings of the National Academy of SciencesRobert Hoffmantelomerasetissuetranscriptasetumor

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