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The Cavalry Is Coming

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JAMES SCHLETT, EDITOR, [email protected]

James SchlettThe doctor’s office has long served as the front line in the fight against disease and age-related ailments. Here, the undiagnosed threat is as dangerous as the undetected enemy. And in a scenario that would make most military generals queasy, the medical profession’s scouts — diagnostic technicians — commonly operate not in advance of the front, not at it, but behind it in a clinical laboratory. That is usually the most practical place to maintain bulky diagnostic equipment.

However, as two articles in this month’s BioPhotonics illustrate, the optical cavalry is coming to the point-of-care (POC) level. The cover story, “Using Photonic Components to Design and Build Life Science and Analytical Instruments” (read article), by Richard Simons at Excelitas Technologies Corp., illustrates how flow cytometers, which clinical laboratories currently use to diagnose and monitor diseases such as HIV/AIDs and blood cancers, can move to the front lines as POC devices.

In “Advances in Laser Diodes Can Bring Portability to Point-of-Care Photoacoustic Systems” (read article), Celine Canal and Andreas Kohl at Quantel similarly highlight the needs for photoacoustic systems at the POC level, the challenges with packaging such technology into portable devices, and how laser diodes can help manufacturers overcome those obstacles. The ability to use portable photoacoustic systems to obtain structural and functional intelligence on blood vessels and tissues — and monitor a disease at its early stages — could give clinicians an edge in their fight against chronic diseases.

Also be sure to read “Fluorescence Lifetime Imaging Made Easy” by Gerhard Holst at PCO AG, (read article). Holst will also give a free webinar on on FLIM in the frequency domain on April 14.

Whether they are large or small, portable or fixed, biophotonic devices can have a tremendous impact on the medical industry. Their reach is far. The drive to develop POC devices will not alter that reach but will certainly change where photonics can touch people’s lives.

Mar 2016
flow cytometry
A method of measuring the characteristics of microscopic particles, usually cells, as they flow in a fluid stream through a beam of light. Particles may be stained with fluorescent dye and the fluorescence detected via laser illumination.
photoacoustic imaging
Abbreviated PAI. An imaging modality with a hybrid technique based on the acoustic detection of optical absorption from endogenous chromophores or exogenous contrast agents. Light is absorbed by the chromophores and converted into transient heating, and through thermoelastic expansion there is a resulting emission of ultrasonic waves. In tissue, ultrasound scatters less than light, therefore PAI generates high-resolution images in the diffusive and optical ballistic regimes compared to purely...
BiophotonicsEditorialJames Schlettflow cytometryphotoacoustic imagingFLIMfluorescence lifetime imaging microscopyPoint-of-carePOCAmericasEuropelasersflow cytometers

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