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BioPhotonics: April 2008

BioPhotonics
 April 2008


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FEATURES
Raman Spectroscopy Meets Flow Cytometry In flow cytometry, which performs high-speed optical analysis of single cells, suspensions of cells are hydrodynamically focused single file through a laser beam (Figure 1). The light scatter provides information about gross morphological features (size and granularity), and fluorescence from labeled antibodies or other probes reports molecular features of cells that provide information about...
Tip-Enhanced Raman Spectroscopy for Bioanalysis A fundamental goal in the life sciences is to understand how the elemental building blocks (nucleobases, amino acids, etc.) are composed in living organisms. Chemical processes in cells are carried...
Raman Spectroscopy Analysis of Polymorphs Some molecules with the same chemical formula can have different crystal structure forms — called polymorphs. There are two ways in which crystal structures can arise: arrangement (or packing)...
Nanotechnology and Photonics Join Forces in Biomedicine In the recent past, biology has shifted from the microscale to the nanoscale, from the level of the cell to that of viruses and of cellular constituents such as proteins, nucleic acids and most...
Magnetic Resonance Imaging Moves Ahead MRI, which allows doctors and clinicians to peer inside the body without the use of ionizing radiation, is particularly useful for imaging soft tissues, which is why athletes often go into a scanner...
POST SCRIPTS
Iron crystals may play a role in neurodegenerative diseases Although iron is necessary for some cellular functions, it also can cause damage in certain forms. For example, iron deposits in the brain may contribute to neurodegenerative diseases such as Parkinson’s, Huntington’s and Alzheimer’s. Optical microscopy has revealed that iron-loaded transferrin tends to aggregate. Images reprinted with permission from Angewandte Chemie. The iron ions (Fe3+)...
AS WE GO TO PRESS
Eyes provide insights into multiple sclerosis A technique that relies on infrared scanning of the eyes has been developed to measure the severity of symptoms that people with multiple sclerosis suffer as a result of slight changes in their core...
GFP trapped in a nanodrop Researchers at the National Institute of Standards and Technology in Gaithersburg, Md., have developed a technique to contain single protein molecules within optically trappable aqueous nanodroplets....
Soil bacteria survive on antibiotics alone Researchers at Harvard Medical School in Boston and at Harvard University in Cambridge, Mass., have cultured hundreds of soil bacteria that can subsist on antibiotics alone as their source of carbon...
Three-dimensional virus image captured with 4.5-Å resolution Single-particle electron cryomicroscopy recently helped a group of researchers to capture a 4.5-Å-resolution 3-D image of the capsid of ε15, a double-stranded DNA bacteriophage — a virus that...
BREAKTHROUGHMEDIA
Online optics forum A redesigned Web site launched by Edmund Optics Inc. presents the company’s optical products, components and instruments while providing new product selection and application tools as well as enhanced navigation. It features an online discussion forum designed to complement the company’s technical support. This global resource allows users to connect with each other and with the company’s...
Photonic products Published by Hamamatsu Corp., Hamamatsu News, 2008, Volume 1, details new products such as multipixel photon counters with an active area of 3 × 3 mm, back-thinned CCD image sensors for...
Lasers, optics Targeted to engineers, scientists, educators and students, “Newport Resource 2008/2009” details optics, lasers, light sources, spectroscopy instruments, photonic and optomechanical products, and...
Monochromators The brochure titled “The DeltaNu DNS Series of Monochromators/ Spectrographs” from Intevac Inc. details the compact, short-focal-length DNS-150 model with 0.4-nm resolution for applications that...
Cellular functions Part of the “Principles and Practice” series, the 472-page book Imaging Cellular and Molecular Biological Functions presents essays by experts in the field for scientists and students who are...
Microscopy supplies The January 2008 issue of the “EMS Newsletter” details supplies and equipment for microscopy, histology, scanning microscopes, benchtop cooling and storage, and general laboratory requirements,...
Optical trapping kit Arryx Inc. has released a brochure on its HOTkit holographic optical trapping kit, which enables researchers to implement advanced trapping capabilities on their own optical benches. The four-page...
Wavefront optics The volume Wavefront Optics for Vision Correction is written for vision-research scientists, ophthalmic device engineers and clinicians who are working to correct their patients’ vision. The 363-page...
Research products MP Biomedicals LLC has released its 2008-2009 catalog, which details more than 50,000 products for research in the life sciences, molecular biology, and bio- and immunochemistry. The 1412-page...
PRODUCTS
Light pipes Docter Optics GmbH offers precision-molded optical glass light pipes, which are employed for homogenizing, conducting and reshaping light for use in a variety of optical equipment and assemblies. According to the company, it can volume-produce the pipes in nearly any shape or size. The company develops custom pipes with a high slenderness ratio and, to simplify assembly, with a plano, ellipsoid,...
Docter Optics SE
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Motion control tools Maxon Precision Motors Inc. has introduced the Freedom Series single-axis motion control system, which offers users a choice of four brushless motor options ranging from 16 to 40 mm in diameter and...
maxon precision motors Inc.
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Active fibers Nufern has expanded its line of NuPower active fibers with three polarization-maintaining double-clad types that are complemented by the availability of matched passive fibers for component and...
Nufern
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Laser photocoagulation Coherent Inc. has unveiled two optically pumped semiconductor lasers for photocoagulation treatment of wet-form macular degeneration and of diabetic retinopathy. The OPSL-532-5 is a 5-W green laser...
Coherent Inc.
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Confocal microscope Leica Microsystems Inc. has introduced the TCS LSI, a macrozoom confocal microscope for in vivo imaging of model organisms. The device has a 16:1 optical zoom that offers high magnification and...
Leica Microsystems
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Half-ball lenses Moulded Optics GmbH offers a standard line of precision-molded micro half-ball lenses from crown (nd = 1.5230), borosilicate (nd = 1.4730) and high-refractive (nd = 1.62000) glass materials in...
Moulded Optics GmbH
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Dental imaging system The GXCB-500 cone beam 3-D dental imaging system from Gendex Dental Systems features a field of view that can be extended up to 14 cm in diameter and up to 8 cm in height to provide a jaw or...
Gendex Dental Systems
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FT-Raman spectrometer Bruker Optics Inc. has unveiled its MultiRam stand-alone Fourier transform (FT) Raman spectrometer, which is suitable for demanding research applications in academic, industrial and government...
Bruker Optics Inc.
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Laser scanning microscope Featuring improved femtosecond multiphoton technology, the LSM 710 NLO laser scanning microscope from Carl Zeiss MicroImaging Inc. is suitable for basic and biomedical research applications. Offering...
Carl Zeiss Microscopy LLC
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4-megapixel camera The Quad-RO: 4320, a 4-megapixel fiber optically coupled CCD camera, has been released by Princeton Instruments. The device has applications in x-ray microtomography and phase contrast imaging, and...
Teledyne Princeton Instruments
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Dichroic beamsplitter Semrock Inc. has announced the addition of a second-harmonic-generation dichroic beamsplitter to its BrightLine range of nonlinear microscopy filters for multiphoton biological imaging. The filters’...
IDEX Health & Science - Semrock Optical Filters
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Hyperspectral imaging BaySpec Inc. has introduced a range of OEM hyperspectral imaging spectrographs to provide three-dimensional images for atmospheric composition analysis, precision farming, food safety inspection and...
BaySpec Inc.
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Labeled beta-amyloid AnaSpec Inc. has announced beta-amyloid peptides prelabeled with fluorophores to accelerate investigation of their role in Alzheimer’s disease. The fluorescent labels include members of the company’s...
AnaSpec
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Flat panel monitor NEC Display Solutions of America has introduced the MultiSync MD21GS-5MP flat panel monitor, which is designed for medical imaging applications, including mammography and PACS. The gray-scale display...
NEC Display Solutions of America
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Digital mammography Siemens Medical Solutions has released the Mammomat Novation S, a digital mammography system to improve clinical screening work flow. The system features the syngo-based acquisition workstation for...
Siemens Medical Solutions USA Inc.
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Beam expanders The compact design of the TechSpec BeamX laser beam expanders from Edmund Optics Inc. makes them suitable for integration into a variety of optical systems. The devices provide diffraction-limited...
Edmund Optics Inc.
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Probes Spectrum Detector Inc. has introduced the delta series analog and digital radiometer and joulemeter probes. The probes can be plugged into an analog power supply and combined with oscilloscopes and...
Gentec-EO USA Inc.
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Portable Raman systems The RMP-300 series portable Raman spectrometer systems from Jasco Inc. incorporate a fiber optic probe with a small X-Y-Z stage, a compact laser, a high-throughput spectrograph and a CCD detector....
JASCO Inc.
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Reflectance materials Offering 96 to 98 percent reflectance, the Spectralon and Spectraflect materials and coatings from Labsphere Inc. provide a high level of uniform light integration in light-collection tubes and...
Labsphere Inc.
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Femtosecond laser The Trestles Finesse tunable Ti:sapphire femtosecond laser from Del Mar Photonics Inc. combines the Finesse diode-pumped laser with the Trestles Mini Ti:sapphire oscillator. It delivers >500 mW...
Del Mar Photonics Inc.
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Hyperspectral sensors Headwall Photonics has unveiled two hyperspectral sensors in the Hyperspec family that can be used for UV and color measurement applications. One sensor measures across the 380- to 780-nm VIS region,...
Headwall Photonics Inc.
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Multipurpose microscope The AZ100M Multizoom multipurpose zoom microscope from Nikon Instruments Inc. offers motorized controls. When combined with the company’s Digital Sight control units, the device can be controlled...
Nikon Instruments Inc.
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Laser line filters Tunable laser line filters from Photon etc. Inc. remove unwanted plasma lines and fluorescence from laser sources over the full spectral range with high pointing stability and signal throughput....
Photon Etc.
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Detection module The id400 from id Quantique is based on a cooled InGaAsP/InP avalanche photodiode optimized for 1064-nm single-photon detection and on a fast sensing and quenching electronic circuit. Featuring...
ID Quantique
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Thermoelectric module Nextreme Thermal Solutions Inc. has unveiled the microscale ultrahigh packing fraction OptoCooler module for cooling and temperature control requirements in optoelectronic and medical applications....
Nextreme Thermal Solutions Inc.
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Stage adapter Bioscience Tools has released a microscope stage adapter that provides a flexible working area to place accessories required for high-resolution live-sample imaging, including media exchange, test...
Bioscience Tools
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Laser meter The Vega handheld meter for laser beam measurement has been released by Ophir-Spiricon Inc. The device is available with either a digital or analog needle display and features an illuminated color...
Ophir, Photonics
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Linear stage The AG-LS25 is a miniature linear stage from Newport Corp. that comes with the Agilis piezo step direct motor and features 12-mm travel and 50-nm minimum incremental motion. A precision limit switch...
MKS/Newport
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Zoom lens Qioptiq Imaging Solutions Inc. has released an improved version of its Optem Zoom 125C microimaging lens system, offering a 50% gain in illumination uniformity across the entire field of view at low...
Qioptiq
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Diode laser stacks Passively cooled quasi-continuous-wave 808-nm diode laser stacks are available from Jenoptik Laserdiode GmbH and Jenoptik Diode Lab GmbH. For pulse durations up to 300 μs and duty cycles up to...
Jenoptik Laser GmbH, Healthcare & Industry
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PACS system Visage Imaging has unveiled the CS Thin Client/Server, which can be integrated with an existing picture archiving and communications system (PACS) to provide efficient server-based 2-, 3- and 4-D...
Visage Imaging
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White-light lasers Toptica Photonics AG is offering three white-light lasers: widely tunable visible lasers, and visible and infrared supercontinuum lasers. The tunable visible laser has a bandwidth of 1 nm and a...
Toptica Photonics AG
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Thawing station Porvair Sciences Ltd. has released the MicroStream microplate thawing station, a device that circulates ambient air across the base of a frozen microplate or tube rack to thaw samples evenly without...
Porvair Sciences Ltd.
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Miniature lasers Snake Creek Lasers has announced its MiniGreen ETR series rugged miniature diode-pumped solid-state lasers. The lasers are packaged in a standard semiconductor can for integration flexibility,...
Advanced Photonic Sciences LLC
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UV spectrometer The Model 248/310 XUV spectrometer from McPherson Inc. works from 1 to 200 nm. With vacuum-tight seals for the 10–6 t vacuum region, the spectrometer optionally can be prepared for use in the...
McPherson
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Spectroradiometers FluxData Inc. has released the FD-1840 series high-performance NIST-traceable spectroradiometers. The modular devices include a small handheld ergonomic spotting scope, a VIS/NIR-corrected lens, a...
FluxData Inc.
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Vibration isolation The KL-VIP vibration isolation platforms from klughammer industrie GmbH intercept vibrations that otherwise would be transmitted to sensitive equipment such as microscopes. The steel or aluminum...
Klughammer GmbH
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Optics toolkit An adaptive optics toolkit that allows for the quick installation of optics into research systems has been released by Thorlabs Inc. and Boston Micromachines Corp. The kit includes a Shack-Hartmann...
Thorlabs Inc.
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Bandpass filters Barr Associates Inc. has unveiled a line of near-IR bandpass filters that are available in a variety of bandwidths and with out-of-band blocking that is suited for the responsivity range of common IR...
Materion Precision Coatings
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CCD camera JAI Inc. has released the AG-7000 intensified CCD camera for low-light applications. Offering standard RS-170 analog video output for connection to monitors and image acquisition cards, the device...
JAI Inc.
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Diode laser modules Dilas has introduced conduction-cooled fiber-coupled diode laser modules that can be used for medical treatments and for solid-state laser pumping. In the modules, diode laser bars with 1550-nm,...
DILAS Diodenlaser GmbH
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Photon counters Zecotek has introduced single-photon-counting semiconductor-based micropixel avalanche photodiodes (MAPD) suitable for incorporation into PET or SPECT scanners, DNA sequencers, flow cytometers or...
Zecotek Photonics Inc.
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Digital microscope The VHX-600 series digital microscopes from Keyence Corp. of America offer a depth of field that the company says is at least 20 times greater than that of conventional microscopes. The 54-megapixel...
Keyence Corp.
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BIOPHOTONICS 2008
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