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BioPhotonics: September 2006

BioPhotonics
 September 2006


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FEATURES
FRET Ventures Out of the Lab Förster resonance energy transfer (FRET) offers a unique means of visualizing biological activity. The technique uses two molecules, a donor and an acceptor. Upon excitation, if the molecules...
Nanobarcodes Check Out Genes Genes carry information that controls the physical development and behavior of every biological organism. Gene expression changes dynamically in living cells and manifests as patterns with numerous...
Optical Traps Illuminate the Subcellular World Optical trapping has been utilized in endeavors as varied as microfabrication, particle sorting and the study of nonequilibrium thermodynamics. The technique, also known as optical tweezing, is...
Watching Golgi Maturation Within cells, the Golgi apparatus gets things where they need to go. An organelle found in all eukaryotic organisms, the Golgi apparatus primarily takes in protein-containing vesicles, then modifies,...
RAPIDSCAN
FRET-based drug screen detects kinases Kinases switch cellular pathways on and off by phosphorylating cellular components. They are ideal drug targets because drugs that target them can control entire pathways. Although Förster...
3-D model reveals cancer cell motility Most cancers become fatal when cells break away from the primary tumor and travel through the bloodstream to other parts of the body, where they settle and divide once again. Pharmaceutical companies...
Single-cell elasticity measured by atomic force microscopy The effect of external forces on living cells holds importance in areas of study such as tissue engineering and cancer research. Forces induce biological transformations on the cell that can alter...
New simulations tell the whole tooth Spectral measurements can be used to indicate tooth decay and to help developers of dental prostheses approximate tooth color. When researchers use the radiative transport equation to calculate light...
Luciferase-based cancer drug screen tested Because the p53 gene has mutated and does not function properly in more than half of all human cancers, researchers developed a luciferase-based bioluminescent assay that detects restored p53 gene...
MRI-guided ultrasound delivers drug to brain The blood-brain barrier prevents harmful substances from entering the brain, but it also obstructs the passage of beneficial drugs, necessitating invasive procedures to deliver them. The breast...
MEMS-based scanning device facilitates microendoscopy Line-scanning rates of up to 1 kHz are important for imaging fast biological processes such as blood flow and neuronal activity. However, conventional scanning mechanisms that offer fast acquisition...
Olympus Tokyo-based Olympus has relocated its headquarters for the Americas from Melville, N.Y., to Center Valley, Pa. The commonwealth used economic incentive programs to attract the company, and the...
Ophthalmic Imaging Systems Inc. Ophthalmic Imaging Systems Inc. of Sacramento, Calif., will partner with International Vision Network, a Baltimore-based division of the International Physician Networks, and with AmerisourceBergen...
Gordon and Betty Moore Foundation The Gordon and Betty Moore Foundation of San Francisco has given $5.6 million to California Institute of Technology in Pasadena to create the Center for Integrative Study of Cell Regulation. The...
Affymetrix Inc. Affymetrix Inc. of Santa Clara, Calif., has given nonexclusive access to Epigenomics AG of Berlin for its microarray technology. With this agreement, the German company will be able to develop and...
PerkinElmer Inc. PerkinElmer Inc. of Wellesley, Mass., has announced two multiyear partnerships with Johns Hopkins University of Baltimore and with the University of Birmingham in the UK. Centered on...
Boston Instruments LLC Boston Instruments LLC of Chelmsford, Mass., has acquired Pro2Kem Inc. in an effort to develop and commercialize microengineered analysis systems — capable of measuring molar mass, size and...
Health Discoveries Corp. Health Discoveries Corp. of Savannah, Ga., has entered into a nonexclusive global licensing agreement with Bruker Daltonics Inc. of Billerica, Mass. The agreement allows the latter company to combine...
InSightec Ltd. InSightec Ltd., a subsidiary of Elbit Medical Imaging Ltd. of Tel Aviv, Israel, has signed an agreement for an internal round of financing from investors and from its parent company, from GE Capital...
Hyphenated Systems Hyphenated Systems of Burlingame, Calif., will provide Purdue University’s microfluidics laboratory in West Lafayette, Ind., with a 3-D microfluidics analysis platform known as 3Dmap. The...
Sandia National Laboratories Sandia National Laboratories of Livermore, Calif., and Monsanto Co. of St. Louis have announced a three-year research collaboration in which the former’s imaging and analytical technologies...
Ciphergen Biosystems Inc. Ciphergen Biosystems Inc. of Fremont and Bio-Rad Laboratories Inc. of Hercules, both in Calif., have signed an agreement in which the latter will acquire the former’s proteomics instrument...
Schering AG Schering AG of Berlin and Avid Radiopharmaceuticals Inc. of Philadelphia are collaborating to develop diagnostic imaging agents for Alzheimer’s. The compounds, made by Avid, bind to amyloid...
BioMachines Inc. BioMachines Inc. of Research Triangle Park, N.C., will expand service offerings through its newly established Applied Proteomics Services group. The new division is the result of an agreement with...
AS WE GO TO PRESS
Brain stimulation and functional MRI work together Researchers at University College London’s Institute of Cognitive Neuroscience have found that human peripheral vision can be positively affected by stimulating parts of the brain with brief electromagnetic pulses. Led by Christian C. Ruff and Jon Driver, they applied transcranial magnetic stimulation to a section of the frontal cortex — which plays a role in generating eye movements...
Nanowire bar codes enable detection of biowarfare agents A team of researchers from California has introduced metallic-striped nanowires to aid in detecting biological warfare agents with optical reflectance and fluorescence imaging. As described in...
Flower color offers a warm welcome to bees Pollinators often use floral color signals as an indication of nutritional reward. Because bees have to maintain a certain body temperature, floral heat could be an additional incentive for them to...
MRI boosts confidence in brain tumor treatments Patients with brain tumors and their physicians alike soon may have more confidence in surgical treatment recommendations, thanks to the effects of preoperative functional MRI of language and motor...
Brain scans reveal tobacco addiction mechanism Many smokers express the desire to stop, and although many receive extensive treatments, fewer than half succeed in stopping long term. It has long been known that nicotine is highly addictive, but...
BREAKTHROUGHMEDIA
Microarray research Affymetrix Inc. has launched an online magazine that features articles on aspects of GeneChip and other microarray-based experiments. Titled “Affymetrix UserForum,” the resource provides...
Process analyzers A supplier of encoded photometric IR spectroscopy analyzers, Aspectrics Inc. has redesigned its Web site to provide information on its products and their applications and on corporate development,...
Spectroscopy resource A brochure from Princeton Instruments/Acton details the company’s spectroscopy offerings, including spectrometers, spectrographs, optical designs, WinSpec software, hybrid sensor technology,...
Biomedical engineering Part of the “Artech House Engineering in Medicine & Biology Series,” the volume Intelligent Systems Modeling and Decision Support in Bioengineering covers the analysis, design and...
Nano-optics guide Principles of Nano-Optics provides an overview of the theoretical and experimental concepts of the field. Optical phenomena relevant to the nanoscale in areas ranging from quantum optics to...
Laboratory supplies Polysciences Inc. has released its 2006-2007 catalog for laboratory, chemical and electronics industry research professionals in fields such as histology, microscopy, polymer chemistry and the life...
Microscopy handbook With more than 122 contributing authors, the third edition of the Handbook of Biological Confocal Microscopy is an authoritative source of information on all forms of 3-D light microscopy and on...
Proteomics research Application Note MT-83 from Bruker Daltonics Inc. is titled “Accurate Quantification with ICPL: The Quantification Study of the ABRF Proteomics Research Group 2006.” The downloadable...
Adaptive optics With contributions from experts in the field, Adaptive Optics for Vision Science: Principles, Practices, Design, and Applications is devoted to the fundamentals of the technology. Part of the...
Photon counting The PCEdu-1 photon Counting Fundamentals package is an entry-level lecture and laboratory tutorial on low-light sensing or semiconductor device physics and is suitable for OEM or academic...
POSTSCRIPTS
These Ants Don’t Follow the Sun Desert ants (Cataglyphis fortis) don’t necessarily look to the sun for directional cues. To find their way, they typically navigate by the global pattern of polarized skylight, a property of light normally invisible to the human eye. Although it has been known that ants, as well as bees, have used polarized skylight as a compass cue, it was thought that they used it only as a backup to...
PRODUCTS
Image sensor The CCD 3041 full-frame image sensor from Fairchild Imaging replaces the company’s CCD 442A and 447 models. The device is suitable for scientific, medical and industrial digital imaging applications. Its focal plane array consists of 2048 x 2048 pixels, delivering 4-megapixel resolution. The pixel pitch of 15 μm provides a 16-bit dynamic range, which can be enhanced by the device’s...
BAE Systems Sensor Solutions
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LED light source CoolLed Ltd. has released precisExcite, a LED light source for fluorescence microscopy that is suitable for working with live cell samples, fixed tissue sections, plant materials and drosophila...
CoolLED Ltd.
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Data acquisition PicoQuant GmbH has released data acquisition software version 6.0 for its TimeHarp 200 time-correlated single-photon-counting board. The software includes a real-time correlator for fluorescence...
PicoQuant GmbH
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Imaging software Version 6.0 of the Image-Pro Express imaging software from Media Cybernetics Inc. offers image processing tools, including edge filters for object identification, fast Fourier transform capabilities...
Media Cybernetics Inc.
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Camera adapter A camera adapter from Scanlab AG provides vision for scan heads in machine vision applications, such as simultaneous process control or determination of workpiece orientation. Designed for...
SCANLAB GmbH
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Scanning probe Veeco Instruments Inc. designed the Multimode V and Dimension V scanning probe microscopes to measure small and large objects, respectively. They can measure characteristics such as topography,...
Veeco Instruments Inc.
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Linear stage The SQL-3405 linear positioning stage measures 25 x 25 x 10 mm and has a 5-mm travel range, maintaining automated “set and hold” micropositioning for optical microscopy, laser alignment...
New Scale Technologies Inc.
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Portable microscope Designed for the medical professional, field operative or mobile laboratory, the Evolution microscope from Pyser-SGI Ltd. is portable, lightweight and hand-size. It is available in bright-field and...
Pyser Optics Ltd.
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Mass spectrometry The improved ultrafast, 2-μm-pore MCP TOF detector offered by Burle Electro-Optics Inc. is suitable for mass spectrometry applications. The detector now incorporates the patent-pending MountingPad...
Photonis Technologies
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Deconvolution software Available for Macintosh, Linux and Windows, version 2.9 of Huygens deconvolution software from Scientific Volume Imaging bv processes all data sets per stack and reads all file formats in batch...
Scientific Volume Imaging
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Spectroradiometer The GS-1290-X series spectroradiometers from Gamma Scientific are suitable for applications in display and light source measurement and in LED and retroreflective material color measurement....
Gamma Scientific
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PCI digitizer AlazarTech Inc. has announced the ATS660, a 16-bit PCI waveform digitizer designed for OEMs and R&D customers who are involved in radio-frequency signal analysis, biomedical imaging, ultrasonics...
Alazar Technologies Inc.
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Telecentric lenses The TML-HP series telecentric lenses from Edmund Optics enable scientists and vision systems designers to make high-accuracy noncontact measurements of small objects. They are available in three...
Edmund Optics Inc.
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FRET software Version 4.5 of AxioVision FRET software by Carl Zeiss allows for all microscope, camera and image data at each processing stage and provides unrestricted selection of filters from the setup menu. It...
Carl Zeiss Spectroscopy GmbH
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Faraday cage Kinetic Systems Inc. has launched the Faraday Cage/Darkbox for use with vibration-isolation systems. The cage uses solid, electrically continuous aluminum walls to protect sensitive devices from...
Kinetic Systems Inc.
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Digital camera adapter Available from klughammer industrie gmbh, the KL-MVP digital camera adapter kit connects almost any digital camera with threaded lenses to microscopes. The adapter kit fits hundreds of popular...
Klughammer GmbH
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UV pump probe Clark-MXR Inc., has unveiled UV TAPPS, a transient absorption pump-probe system that provides broadband femtosecond-resolution pump-probe spectroscopy for investigation of chemical and biological...
Clark-MXR Inc.
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Ultrafast amplifiers Spectra-Physics, a division of Newport, offers the Spitfire Pro XP and the Spitfire Pro 5W ultrafast amplifiers for amplifying femtosecond oscillators. Both versions use a patented one-Pockels-cell...
Newport Spectra-Physics GmbH, Photonics Solutions Div.
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Laser controller unit Pavilion Integration Corp. has announced the WhisperIT CDRH-certified stand-alone controller unit for operating and controlling WhisperIT lasers. The compact controller allows simple adjustment of...
Pavilion Integration Corp.
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Piezoelectric stages The P-628.2CD X-Y closed-loop piezoelectric stages from PI (Physik Instrumente) LP are suitable for use by nanometrology/precision microscopy instrument designers to probe large areas. The stages...
PI (Physik Instrumente) LP, Motion Control, Air Bearings, Piezo Mechanics
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CMOS cameras Mightex Systems has released a series of color and monochrome CMOS cameras for industrial and scientific applications, such as microscopy and biomedical imaging. The MCN-B013-U and MCN-C013-U are,...
Mightex Systems
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OEM laser module Toptica Photonics AG has introduced the OEM laser module dfTune for applications in absorption spectroscopy, gas sensing, lidar seeding, interferometry and difference frequency mixing for tunable...
Toptica Photonics AG
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Eye imaging Nidek Co. Ltd. has produced the Auto Ref/Keratometer ARK-530A/ARK-510A and Auto Refractometer AR-330A/AR-310A for ophthalmic and optometric diagnostics. The eye care products combine the measurement...
NIDEK CO. LTD.
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LED light lines Volpi USA has announced a series of high-intensity surface-mount-device LED light lines featuring increased intensity, extended life and highly uniform light output when compared with light lines...
Volpi USA
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Imaging software Available from Prior Scientific Instruments, Pax-it imaging software provides flexibility in image management and storage. The software enables users to capture and archive image files from...
Prior Scientific Instruments Ltd.
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Camera phone imaging Varioptic SA has launched an addition to its Arctic series of autofocus lenses. Suitable for low-footprint camera modules, such as slim camera phones, the Arctic 416 can obtain sharp, crisp focus in...
Corning Varioptic Lenses
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Metabolomics software Version 7.5 of the KnowItAll Informatics System from Bio-Rad Laboratories Inc. features an edition for metabolomics research. The program includes Infometrix’s Pirouette chemometrics software,...
Bio-Rad Laboratories Inc., Informatics Div.
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UV laser The Paladin Compact UV laser produced by Coherent Inc. delivers 2-W, 355-nm quasi-CW output with a 120 ±2-MHz repetition rate. When operated between 10 Hz and 2 MHz, it has less than 1% rms...
Coherent Inc.
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Positioning controls Owis GmbH has released the PS 90 and PS 30 high-performance positioning controls. The PS 90 has a modular configuration, up to nine axes, a USB 2.0 interface, parallel operation of different drive...
OWIS GmbH
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IR CCD spectrometer Newport Corp. says that its Oriel InstaSpec IR CCD achieves a greater resolution and a sensitivity equivalent to that of LN2 detectors because the gain occurs within the CCD. With an array of 1024 x...
MKS/Newport
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25-mW laser module Photonic Products Ltd. has added a 25-mW version to its line of 405-nm laser diode modules with TTL modulation. The module produces a stable 2 x 3.5-mm beam and has an antireflection-coated...
Photonic Products Ltd.
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Eye-analogue sensor The SFH 5711 ambient light sensor from Osram Opto Semiconductors Inc. precisely matches the sensitivity curve of the human eye, making it suitable for applications where automatic changes in display...
Osram Opto Semiconductors Inc.
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CCD detector Rigaku Americas Corp. has launched the Saturn 210 large-area CCD detector, which has a 2 x 2 array of Kodak chips, a 210 x 210-mm active area and a readout speed of 4 x 2 MHz. The detector combines...
Rigaku Americas Corp.
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Skin modeling Breault Research Organization has launched a multilayered realistic skin modeling technique for disease and disorder research. The system allows users to control the chromophore concentrations in...
Breault Research Organization Inc.
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Frame grabber Matrox Imaging has released lower-cost models of its Solios single-camera frame grabber, featuring acquisition speeds of up to 66 to 85 MHz and a 64-MB acquisition buffer. The XCL-B and XCL-F support...
Matrox Imaging
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Microscope camera The 2-megapixel DP20 digital microscope camera from Olympus America Inc. can display a 1600 x 1200 image at 15 fps. It can be operated without a PC and interfaces directly to a monitor or to a...
Evident
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X-ray tube Incoatec GmbH and Bruker AXS Inc. have introduced the IμS x-ray microsource, an x-ray generator that incorporates a 30-W microfocus sealed tube with Montel multilayer x-ray optics. The device has...
Bruker AXS Inc.
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Indenter Asylum Research has released the NanoIndenter module to complement its MFP-3D atomic force microscope. Unlike cantilever-based indenters, the device drives the tip perpendicular to the sample. It...
Oxford Instruments Asylum Research
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Diode lasers Lissotschenko Mikrooptik (Limo) GmbH has introduced a 25-W fiber-coupled diode laser that emits a 10 x 10-mm beam with divergence of 2 x 2 mrad. The passively cooled LIMO25-C10310-DL980’s power...
LIMO GmbH
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BIOPHOTONICS 2006
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