Request InfoCoolLED Ltd.CoolLed Ltd. has released precisExcite, an LED light source for fluorescence microscopy that is suitable for working with live cell samples, fixed tissue sections, plant material and larvae preparations. With a remote control pod, a mixing and collimating unit, and a pair of lightguides, the instrument has advantages over conventional light sources. It generates no radiant heat and can be controlled to avoid photobleaching. It also requires no bulb alignment and offers a lifetime of more than 10,000 h. The device produces three selectable wavelengths that match commonly used fluorescent dyes....See full productRelated content from Photonics MediaPRODUCTSPromoted Content November 2022 IssueLS850 Fully Automated MicroscopeThe powerful, new LS850 Microscope is the latest generation of our fully automated three-channel flagship model and offers the latest advances in optics, cameras, throughput, and user flexibility....Promoted Content September 2022 IssueAward-winning Microscopy IlluminationCoolLED, a global expert in LED microscopy illumination, is helping scientists reach the full potential of their widefield fluorescence microscopy and optogenetics experiments with the popular pE-300...Photonics.com 2/8/2024Fluorescence Imaging LensesThe Melles Griot XPLAN™ CCG Lens Series from IDEX Health & Science are fluorescence microscope imaging lenses for life science and medical applications. The lenses use a larger field of...Promoted Content December 2022 IssueNEW 4-Wavelength LED IlluminationCoolLED has launched its new pE-400 Series Illumination Systems where sophisticated control combines with powerful illumination for cost-effective fluorescence microscopy, from routine to advanced...ARTICLESBioPhotonics Jan/Feb 2024 IssueAlgorithm Targets Microscope ResolutionScientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the...Photonics.com 10/13/2022Imaging System Speeds Diagnosis with Real-Time Biopsy AnalysisResults of a pilot study conducted at the University of Rochester showed that a system based on two-photon fluorescence microscopy (TPFM) enabled rapid diagnosis of nonmelanoma skin cancer through...BioPhotonics Jan/Feb 2024 IssueLabel-Free Imaging Shows Dynamics of Intracellular Cargo TransportUntil now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of...BioPhotonics Jan/Feb 2023 IssueNobel Prize-Winning Techniques Help Resolve Imaging ChallengeUsing a technique that was recently awarded the 2022 Nobel Prize in chemistry, researchers at Cornell University used expansion microscopy to study lipids, the water-repellent, dynamic components...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookNanopositioning: A Step AheadBy its original definition, a nanopositioning device is a mechanism capable of repeatedly delivering motion in increments as small as one nanometer. Lately demands from industry and research have...Photonics HandbookSuperresolution Microscopy: An Imaging RevolutionSuperresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookMeasuring Surface Roughness: The Benefits of Laser Confocal MicroscopyWhen evaluating the surface of a component, surface roughness can be assessed by eye or by rubbing it with a fingertip. Common expressions include “shiny,” “lusterless and...Photonics HandbookMicroscopy Illumination: Considering Nonlaser Light SourcesAs recently as five years ago, shopping for a microscope light source was fairly straightforward. For routine applications, it was tungsten halogen, typically 100 W, while for fluorescence, it was an...WHITEPAPERSPhotonics.com 12/2/2022FISBA READYBeam™ - Compact Powerful Laser SourceThe FISBA READYBeam™ is our answer to customers' increasing demand for compact, powerful, and reliable multicolor laser source that can be easily integrated into existing set-ups. The multicolor...Photonics.com 2/7/2024An Overview of CRISP Autofocus SystemContinuous Reflective Interface Sample Placement (CRISP) system is designed to maintain focus over time, i.e. to compensate for thermal and other factors that may cause the sample to drift out of...Photonics.com 10/19/2023Clean, New Bioenergy Sources: One Molecule at a TimeResearchers at Penn State University are spearheading a multidisciplinary research effort to explore ways to produce bioethanol more efficiently from lignocellulose. Importantly, this is not corn...Photonics.com 9/1/2022Precision Motion and How to Achieve ItNanoscale motion requires fastidious attention to instrumentation, passive controls, and experiment design. Most users have experience in motion control within the sphere of the microscale. In this...WEBINARSPhotonics.com 6/2/2022Advances in LED Illumination for Fluorescence ImagingLED illumination for fluorescence microscopy systems has progressed significantly from a time when LED sources had low optical power and a limited range of wavelengths. While the benefits of LED...Photonics.com 11/12/2020Optical and Electrical Microsystems for Advanced Biomedical Imaging and DiagnosisMedical diagnosis heavily depends on innovative methods for biomedical imaging. New system concepts that combine miniaturized optical MEMS components, such as scanning mirrors and spatial light...Photonics.com 10/24/2023Expansion-Assisted Selective Plane Illumination Microscopy Captures Large and Small Biological DetailRecent advances in tissue processing, labeling, and fluorescence microscopy are providing unprecedented views of the structure of cells and tissues at sub-diffraction resolutions and near single...Photonics.com 10/18/2023Advancing and Extending the Spectral Range for Imaging in Fluorescence MicroscopyFluorescence microscopy has revolutionized life sciences by enabling researchers to study biological samples with exceptional precision. New excitation and illumination light sources and scientific...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionarywide-field fluorescence microscopyWide-field fluorescence microscopy uses either naturally occurring structures or staining with fluorescent tags that are activated by specific wavelengths of light and then emits a different...Photonics Dictionaryelectron multiplication charge-coupled device cameraAn EMCCD (electron-multiplying charge-coupled device) camera is a type of scientific camera specifically designed for low-light imaging applications that require high sensitivity and fast readout...Photonics Dictionaryfluorescence lifetime imagingFluorescence lifetime imaging (FLIM) is an advanced imaging technique that provides information about the lifetime of fluorescence emissions from fluorophores within a sample. Unlike traditional...Photonics Dictionarycalcium indicatorA calcium indicator is a molecule that is sensitive to changes in calcium ion (Ca2+) concentrations in biological systems. These indicators are commonly used in various fields, including cell...VIDEOSPhotonics.com 11/20/2023New ZL41 Cell & Sona sCMOS - Easy, Flexible, Cost-Effective Super Resolution Microscopy - Andor TechnologyEasy and Cost-Effective Super-Resolution to ~100 nm. Andor has introduced two new highly innovative sCMOS cameras, both delivering easy and cost-effective access to super-resolution capabilities and...Photonics.com 1/24/2022Welcome to CoolLEDIntroducing the experts who design and manufacture high performance LED Illumination Systems.Photonics.com 11/20/2023Andor OEM IntegrationsCutting-edge Innovation √ Unparalleled Quality √ Designed-in Reliability √ Custom Designs √ Andor is the trusted choice for OEM integrations, supplying cameras, spectrographs,...Photonics.com 5/2/2022Applied Scientific InstrumentationEstablished in 1990, Applied Scientific Instrumentation is a reknown American company committed to the advancement of science. ASI products have been thoroughly tested and evaluated in numerous labs...PHOTONICS BUYERS' GUIDE CATEGORIESFiber Optic Light-Emitting Diodes (LEDs)Toolmaker MicroscopesPetrographic MicroscopesA petrographic microscope is a microscope equipped with a polarizer, an analyzer and a Bertrand lens to focus on the upper focal plane of the objective. It is used chiefly by mineralogists and...Polarizing MicroscopesCOMPANIESPhotonics Buyers' GuideCoolLED Ltd.CoolLED designs and manufactures cutting edge LED illumination systems for researchers and clinicians using the latest LED technology. Since our team of four introduced the first commercially...Photonics Buyers' GuideExcelitas Technologies Corp.Excelitas Technologies® Corp. is a leading industrial technology manufacturer focused on delivering innovative, market-driven photonic solutions to meet the illumination, optical, optronic,...Photonics Buyers' GuideMad City Labs Inc.Mad City Labs, Inc. is a leading manufacturer of piezo nanopositioning systems and instrumentation capable of sub-nanometer positioning resolution. Our product line of nanopositioners,...Photonics Buyers' GuideAndor TechnologyAndor Technology Ltd is a global developer and manufacturer of high-performance scientific cameras, microscopy systems and spectrographs for academic, government, and industrial applications. Founded...