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Interline CCD Camera Extension
Feb 2010
Andor Technology Ltd., Corporate HeadquartersRequest Info
BELFAST, UK, Feb. 12, 2010 – Andor Technology has expanded its Clara line of scientific interline CCD cameras with the launch of the Clara E. Based around the 1.3-megapixel ICX285 sensor from Sony, it is engineered for high sensitivity, high resolution and a high dynamic range of >6000:1 standard, and higher when binned.

The camera leverages the proprietary and proven UltraVac vacuum process, delivering thermoelectric air cooling performance to -20 °C for reduction of dark current, complementing a low read noise of 3 e- at 1 MHz. Dynamic events can be followed with good quantitative stability via low-noise 10- or 20-MHz readout modes, the data channeled through a USB 2.0 interface that provides plug-and-play connectivity. Proprietary iCam technology and comprehensive input/output functionality enable good acquisition efficiency through live-cell microscopy software, and an accurate field-programmable gate array hardware-generated time stamp ensures absolute temporal precision to 12.5 ns. The compact, robust design and accessible software development kit render the camera suited to OEM integration.

Active pixels are 1392 × 1040, pixel size is 6.45 × 6.45 µm, and the image area is 8.98 × 6.71 mm. Maximum operating frame rate is 11.6 fps. The camera offers 14- and 16-bit digitization and an enhanced baseline clamp for quantitative accuracy of dynamic measurements.

Maximum linearity is 1%, and operating temperature is from 0 to 35 °C ambient. Voltage is 12 V ±5%, maximum current is 3 A at peak cooling, maximum ripple and noise is 200 mV, and maximum total power is 36 W.

Applications include wide-field fluorescence microscopy, living and fixed cells, ion signaling, single-molecule detection, fluorescent proteins, fluorescence in situ hybridization, immunofluorescence, comet assay, high-content screening, and spectral and ophthalmic imaging.


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high-content screening
Also known as HCS, an analytical method designed to collect statistically relevant amounts of quantitative data on many parallel cell populations or processes within cells through the combination of microtiterplates, high-resolution imaging, automated microscopy, fluorescent or bright-field sensors and image analysis software.  
The technique that uses light to detect and analyze the antibodies produced by a specimen stained with an organic dye.
wide-field fluorescence microscopy
Wide-field fluorescence microscopy uses either naturally occurring structures or staining with fluorescent tags that are activated by specific wavelengths of light and then emits a different wavelength. The microscope itself is set up with a light source (commonly an arc lamp, metal halide or LED) that emits the excitation light to the sample. The whole field of view is illuminated by the excitation light, hence the name, wide-field. The quality of the wide-field fluorescence is dependent upon...
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