May 2010Wyatt Technology Corp.Request Info
Wyatt Technology Corp. has launched the Möbiuζ, a laser-based
instrument for noninvasive measurement of macromolecular electrophoretic mobilities.
The device provides reproducible data on the mobilities of large particles such
as liposomes and viruslike particles and of protein samples that are hard to measure,
including antibody formulations, bovine serum albumin (BSA) and lysozyme. Through
parallelism of detection, it measures in <1 min, preserving fragile protein samples
and providing sufficient data to average away molecular diffusion and extend the
measurable molecular size range below 2 nm. Detection sensitivity is 2 mg/ml for
lysozyme and 0.5 mg/ml for BSA. Simultaneous measurement of the macromolecular hydrodynamic
radius is available with the WyattQELS (quasielastic light scattering) option, which
uses backward scattered light to determine the sample translational diffusion coefficient.