Carl Zeiss SMT AG has launched Atlas, a powerful hardware and software package, which, in combination with any of the company’s scanning electron microscopes, enables quick and efficient imaging of large-area specimens with nanometer resolution. It is initially being used in the area of neurological research, e.g., for brain mapping, and for traditional routine tasks in histology and pathology. With suitable specimens, unattended operation can acquire multi-image montages that span large fields of view, permitting capture of regions on the millimeter scale with resolution on the nanometer scale in a handful of hours. The built-in viewer software with integrated zoom function facilitates continuous enlargement of the final image from rough overview until nanometer resolution is achieved. Atlas enables acquisition of individual images up to one gigapixel in size (32 k x 32 k), at up to 16-bit pixel depth, and calls upon the suite of SmartSEM microscope automation features to allow automated acquisition of one or more image montages that may exceed one terapixel in size.