Nov 2010LI-COR Biosciences, BiotechnologyRequest Info
Li-Cor Biosciences Inc. has added the IRDye 800CW HA optical probe
to its BrightSite family of optical agents for in vivo imaging. Hyaluronic acid
(HA) is an extracellular-matrix glycosaminoglycan formed from disaccharide units
containing N-acetylglucosamine and glucuronic acid. The probe interacts with various
cell surface receptors, binding to proteoglycans in cartilage and other tissues.
It is suitable for targeting the lymphatic system or tumor cells that overexpress
CD44 receptors and is catabolized by receptor-mediated endocytosis and lysosomal
degradation. The probe can be used on near-IR detection systems.