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Superresolution Microscope

Photonics Spectra
Jan 2011
Nikon Instruments Inc.Request Info
 
Nikon Instruments Inc. has released the N-SIM, a superresolution microscope that operates at speeds enabling the study of microstructures and nanostructures of fixed and living cells with molecular-scale resolution. Based on the Eclipse Ti inverted microscope, the instrument produces twice the resolution of conventional optical microscopes, combining structured illumination microscopy (SIM) technology – licensed to Nikon by the University of California, San Francisco – with the company’s CFI Apo total internal reflection fluorescence 100x oil objective lens that has a numerical aperture of 1.49. N-SIM achieves a time resolution of 0.6 s per frame and is effective for live-cell imaging.


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GLOSSARY
frame
1. To center an image or place it in any part of the television screen desired. Also applies to stills. 2. A single image of the connected multiple images on motion-picture film. 3. The size of the copy produced by a facsimile system. 4. In raster-scanned television, the combination of two interlaced field scans, making a single frame.
inverted microscope
A microscope designed so that the specimen is located face down above the objective.
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