Jan 2011Nikon Instruments Inc.Request Info
Nikon Instruments Inc.’s N-SIM superresolution microscope
is based on structured illumination (SIM) technology developed and licensed to Nikon
by the University of California, San Francisco. Used in conjunction with total internal
reflection fluorescence microscopy, the technology allows the microstructures and
nanostructures of fixed and living cells to be viewed with molecular-scale resolution,
achieving twice the resolution of conventional optical microscopes, even near the
cell membrane. It achieves a time resolution of 0.6 s per frame.