Request InfoApplied Scientific Instrumentation Inc.ASI’s Dual Selective Plane Illumination Microscopy for Cleared Tissue (ct-dSPIM) is one of many light sheet microscope configurations possible using our modular components. This flexible and easy-to-use Selective Plane Illumination Microscopy (SPIM) implementation allows for dual views of large samples such as cleared tissue (ct). We manufacture the optomechanical elements, including the motorized stages and 2D galvos for creating and moving the light sheet. ASI partnered with Special Optics to develop an objective optimized for light sheet imaging of cleared tissue. Lasers and...See full productRelated content from Photonics MediaPRODUCTSPromoted Content June 2023 IssueCobolt Jive™ 561 nm CW Laser – 1 WHÜBNER Photonics, manufacturer of high-performance lasers, showcases the release of a higher power model of the Cobolt Jive 561 nm on the 05-01 Series platform. Now with up to 1 W CW output...Photonics Spectra July 2022 IssueFluorescence Filter SetKnight Optical LLC’s fluorescence filter set range suits the diverse needs of various fluorescence applications that demand high-quality components. Each set comprises an excitation...Promoted Content December 2022 IssueNEW 4-Wavelength LED IlluminationCoolLED has launched its new pE-400 Series Illumination Systems where sophisticated control combines with powerful illumination for cost-effective fluorescence microscopy, from routine to advanced...BioPhotonics Jul/Aug 2023 IssueCW Diode-Pumped LaserHÜBNER Photonics has released a higher power model of the Cobolt Jive™ 561-nm laser on the 05-01 series platform. With up to 1000-mW continuous wave output power, the laser can be...ARTICLESBioPhotonics Nov/Dec 2023 IssueIlluminating the Unseen: Data at Depth with Light-Sheet Fluorescence MicroscopyLight-sheet fluorescence microscopy, also called single plane illumination microscopy (SPIM) is a noninvasive 3D imaging method that employs a sheet of light to illuminate a thin plane of a specimen....Photonics.com 12/9/2022Fiberoptic Components Rebrands as Innofiber: Week in Brief: 12/09/22Fiberoptic Components LLC, a supplier and manufacturer of fiber optic cables and engineered photonic solutions, rebranded as Innofiber — to reflect its commitment to innovation and expertise in...BioPhotonics.com November 2023 IssueLight-Activated Tool Controls Protein Bonds and Tracks Cell AdhesionOptical tools can be used to activate biological functions, but with current methods the effects are slow to appear, and sustained effects require continuous light activation. As a result, these...Photonics.com 5/24/2022Microscopy Methods Pair to Advance Nanoscale Superresolution ImagingResearchers combined stimulated Raman scattering (SRS) with expansion microscopy to develop a single microscopy technique that achieves superresolution vibrational imaging at the nanoscale. A team...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookNanopositioning: A Step AheadBy its original definition, a nanopositioning device is a mechanism capable of repeatedly delivering motion in increments as small as one nanometer. Lately demands from industry and research have...Photonics HandbookNSOM: Discovering New WorldsNSOM is suitable for studies on the mesoscopic scale (several tens to hundreds of molecular dimensions). It has become an important tool in research and applications of semiconductors, organic layers...Photonics HandbookInterferometry: Measuring with LightAn interferometer is an instrument that compares the position or surface structure of two objects. The basic two-beam division of amplitude interferometer components consists of a light source, a...Photonics HandbookMicroscopy Illumination: Considering Nonlaser Light SourcesAs recently as five years ago, shopping for a microscope light source was fairly straightforward. For routine applications, it was tungsten halogen, typically 100 W, while for fluorescence, it was an...WHITEPAPERSPhotonics.com 10/4/2022Product Development Strategies for Electro-Optical SystemsThis whitepaper looks at the unique challenges associated with optical systems by exploring two extremes, an ultra-high precision instrument, and a low-cost consumer product, and the different...Photonics.com 11/21/2023Conceptualizing Super-Resolution Microscopy eBookA clever way to overcome the limitation caused by diffraction is to use 'pointillism strategy', a concept introduced by Rainer Heintzmann in 2005. The idea is to have only one fluorescent emitter...Photonics.com 10/26/2022Methods of Imaging with Photoelastic ModulatorsThis paper highlights a range of options to utilize Photoelastic Modulators (PEMs) with imaging systems to generate full field polarimetric measurements. Due to the resonant nature of the...Photonics.com 2/7/2024An Overview of CRISP Autofocus SystemContinuous Reflective Interface Sample Placement (CRISP) system is designed to maintain focus over time, i.e. to compensate for thermal and other factors that may cause the sample to drift out of...WEBINARSPhotonics.com 1/24/2019Advances in Rapid 3D Imaging of Large Tissue SamplesThis webinar will discuss rapid 3D, multiplexed imaging of large tissue samples, based on recent advances in light-sheet fluorescence microscopy, multiplexed molecular labeling, and optical tissue...Photonics.com 10/25/2018Shareable Advanced Light-Sheet Microscopy Using FlamingoThis webinar will discuss a new model for advanced microscopy, based on shareable, modular instruments. This model, called Flamingo, is designed to bridge the gap between biology and technology....Photonics.com 3/21/2013Techniques in Biophotonic ImagingFREE WEBINAR Sponsored by: Hamamatsu & Applied Scientific Instrumentation Additional Questions & Answers from the webinar are below: Dr. Kimani C. Toussaint Jr. Quantitative...Photonics.com 7/20/2023The Importance of High Spectral Fidelity in Imaging Spectroscopy — From an Application PerspectiveUsing imaging spectroscopy or hyperspectral imaging for useful applications requires the ability to trust the spectral signatures in each pixel. Laboratory technicians typically set up precise and...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionarylight sheet fluorescence microscopyAlso known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. In this method, a light sheet illuminates...Photonics Dictionaryvertical transmitted illuminationWith respect to microscopy, light that is directed through the specimen by a substage condenser.Photonics DictionarybackstreamingThe term used in reference to vacuum systems using oil and diffusion pumps, describes the migration of pump fluids and their decomposition products into the vacuum chamber.Photonics Dictionarymotion controllerIn optics, a motion controller refers to a device or system that precisely controls the movement of optical components, such as mirrors, lenses, stages, or other elements within an optical setup. The...VIDEOSPhotonics.com 11/20/2023Andor OEM IntegrationsCutting-edge Innovation √ Unparalleled Quality √ Designed-in Reliability √ Custom Designs √ Andor is the trusted choice for OEM integrations, supplying cameras, spectrographs,...Photonics.com 11/20/2023Andor's Life Science Research SolutionsAt Andor, it matters to us that the products we develop make a real difference to our customers and contribute significantly to their research across Immunology, Microbiology, Neuroscience, Cells &...Photonics.com 11/20/2023New Dragonfly 600 Confocal Microscope System - Andor TechnologyThe Dragonfly 600 confocal microscope system delivers outstanding multi-dimensional images from subcellular (nm) to whole organism (cm), while significantly boosting productivity. Its unrivalled...Photonics.com 1/24/2022Welcome to CoolLEDIntroducing the experts who design and manufacture high performance LED Illumination Systems.PHOTONICS BUYERS' GUIDE CATEGORIESNear-Field Scanning Optical MicroscopesA near-field scanning optical microscope is a scanning probe microscope that analyzes the surface of a specimen by recording the intensity of light as it is focused through a pipette and raster...Cable Management ProductsFluorescence MicroscopesMedical/Biomedical MicroscopesCOMPANIESPhotonics Buyers' GuideApplied Scientific Instrumentation Inc.Applied Scientific Instrumentation, Inc. (ASI) is a company committed to the advancement of science. Our engineers and technicians have years of experience in aiding researchers with their technical...Photonics Buyers' GuidePrior Scientific Inc.For over 100 years, Prior Scientific has been manufacturing precision optical and electro-mechanical equipment and instrumentation. Prior is a leader in the development of precision motion,...Photonics Buyers' GuideAndor TechnologyAndor Technology Ltd is a global developer and manufacturer of high-performance scientific cameras, microscopy systems and spectrographs for academic, government, and industrial applications. Founded...Photonics Buyers' GuideSutter Instrument CompanyIn 1977, Dale Flaming, a scientist working at the University of California at San Francisco, was having difficulty reliably producing micropipettes. He developed the first electronically controlled...