Close

Search

Search Menu
Photonics Media Photonics Buyers' Guide Photonics Spectra BioPhotonics EuroPhotonics Vision Spectra Photonics Showcase Photonics ProdSpec Photonics Handbook

Light Source for Optogenetics

CoolLED Ltd.Request Info
 
Facebook Twitter LinkedIn Email Comments
Light Source for Optogenetics Researcher Attila Szücs from Eötvös Lóránd University (Hungary) and his team utilise electrophysiology and optogenetics to study the regulation of intrinsic excitability – for example, how different forms of stimulus at the synapse determine neuronal firing. This aspect is really important in the mechanisms which underlie learning and memory storage.

In his lab, the ability to precisely stimulate neurons is of utmost importance, and to drive the firing of neurons under dynamic patch clamp conditions (where the current can be modulated in real time and the effect on action potential directly analysed) they use synaptic stimulus waveforms synthesised by computer.

For optogenetic stimulation, they use the CoolLED pE-4000. The TTL control of the Illumination System allows them to deliver fast, precisely timed sequences of light and evoke action potentials in neurons expressing channelrhodopsin-2.

These protocols can effectively simulate synaptic bombardment and they can precisely control the strength and temporal pattern of the input waveforms. One interesting application is to study various forms of membrane resonance when the synthetic stimulus waveforms are of the oscillatory type. This phenomenon is related to how neurons synchronise at a network level, but there is still much more to understand.

The controllable pE-4000 Illumination System
     •  16 selectable LED wavelengths
     •  Four channels
     •  Function generator for optogenetics
     •  Range of control options including TTL and USB
     •  Broadest and most versatile illumination system available
     •  Compatible with filters and fluorophores of almost any microscope

To find out more on this research:
     •  Szücs, A. & Huerta, R. (2015). J Neurophysiol, 113, 232-243.
     •  Szücs, A., Rátkai, A., Schlett, K. & Huerta, R. (2017). Eur J Neurosci, 46, 2429-2444.
     •  Hernáth, F., Schlett, K. Szücs, A. (2019). Scientific Reports, 9: 13096.


REQUEST INFO ABOUT THIS PRODUCT

* Message:
(requirements, questions for supplier)
Your contact information
* First Name:
* Last Name:
* Email Address:
* Company:
Address:
Address 2:
City:
State/Province:
Postal Code:
* Country:
Phone #:
Fax #:

Register or login to auto-populate this form:
Login Register
* Required

When you click "Send Request", we will record and send your personal contact information to CoolLED Ltd. by email so they may respond directly. You also agree that Photonics Media may contact you with information related to this inquiry, and that you have read and accept our Privacy Policy and Terms and Conditions of Use.
light sourcesoptogeneticscell biologylife sciencesneuroscienceProducts

back to top
Facebook Twitter Instagram LinkedIn YouTube RSS
©2020 Photonics Media, 100 West St., Pittsfield, MA, 01201 USA, [email protected]

Photonics Media, Laurin Publishing
x We deliver – right to your inbox. Subscribe FREE to our newsletters.
X
Are you interested in this product?
When you click "Send Request", we will send the contact details you supply to CoolLED Ltd. so they may respond to your inquiry directly.

Email Address:
Name:
Company:
Stop showing me this for the remainder of my visit
We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.