Request InfoApplied Scientific Instrumentation Inc.ASI has developed a new form of light sheet microscopy with our collaborators in the scientific community. The diSPIM system from ASI is an extremely cell friendly system for imaging live specimens as it only illuminates the region of the specimen that is being viewed, reducing phototoxicity and reducing photobleaching ~7-10 fold. Unlike other SPIM systems, the diSPIM allows the use of conventional mounting and glass coverslips.See full productRelated content from Photonics MediaPRODUCTSPromoted Content November 2023 IssueAutomated Fluorescence, SimplifiedCoolLED’s Amora Series for custom microscopy illumination is based on an established portfolio of off-the-shelf products, adapted to offer unparalleled customization opportunities. This...Promoted Content September 2022 IssueAward-winning Microscopy IlluminationCoolLED, a global expert in LED microscopy illumination, is helping scientists reach the full potential of their widefield fluorescence microscopy and optogenetics experiments with the popular pE-300...Promoted Content October 2023 IssueLED Technology for OEM ApplicationsCoolLED’s Amora Series for custom microscopy illumination is based on an established portfolio of off-the-shelf products, adapted to offer unparalleled customization opportunities. This...Promoted Content May 2023 IssuePowerful LED Illumination for Every ApplicationCoolLED, a global expert in LED microscopy illumination, is helping scientists reach the full potential of their widefield fluorescence microscopy and optogenetics experiments with its broad range of...ARTICLESBioPhotonics Nov/Dec 2023 IssuePhotoacoustic Microscopy Method Delivers Higher SensitivityA multispectral, super-low-dose photoacoustic microscopy (SLD-PAM) system developed by City University of Hong Kong (CUHK) achieves significantly higher sensitivity than traditional optical...BioPhotonics Sep/Oct 2023 IssueDNA-Barcoded Fluorescence Imaging Illuminates Core Cell ComponentsSince many core components of cells — like DNA, RNA, proteins, and lipids — are just a few nanometers in size and substantially smaller than the resolution limit of traditional light...BioPhotonics Jul/Aug 2023 IssueCentury-Old Effect Applied for Study of Embryonic DevelopmentResearchers have applied line-scanning Brillouin microscopy (LSBM), a microscopy technique based on Brillouin scattering, to visualize the mechanical properties of living cells over space and time,...Photonics.com 3/26/2024Traceable Standards Could Speed Development of Quantum TechnologiesDevices that capture light from quantum dots, like chip-scale lasers and optical amplifiers, have made their way from the lab to the commercial market. The transition for newer quantum dot-based...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookSuperresolution Microscopy: An Imaging RevolutionSuperresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookAspheric Lenses: Design ConsiderationsAspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookMicroscopy Illumination: Considering Nonlaser Light SourcesAs recently as five years ago, shopping for a microscope light source was fairly straightforward. For routine applications, it was tungsten halogen, typically 100 W, while for fluorescence, it was an...Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best ApproachThe term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...WHITEPAPERSPhotonics.com 9/27/2023Raman SpectroscopyTo achieve accurate and precise Raman measurements, optical filters play a crucial role in enhancing signal-to-noise ratio, and reducing background interference. This white paper explores the...Photonics.com 1/10/2024Single-Objective Light SheetAn overview of the Single-Objective Light Sheet.Photonics.com 9/1/2022Precision Motion and How to Achieve ItNanoscale motion requires fastidious attention to instrumentation, passive controls, and experiment design. Most users have experience in motion control within the sphere of the microscale. In this...Photonics.com 2/16/2024Rapid Automated Modular MicroscopeOverview of Rapid Automated Modular Microscope.WEBINARSPhotonics.com 8/4/2020An Oblique Plane Light-Sheet Microscope with 200-nm-Scale ResolutionLight-sheet fluorescence microscopy (LSFM) has generated significant interest in the biological community. Not only does it deliver light to only the in-focus portion of a specimen, decreasing the...Photonics.com 10/25/2018Shareable Advanced Light-Sheet Microscopy Using FlamingoThis webinar will discuss a new model for advanced microscopy, based on shareable, modular instruments. This model, called Flamingo, is designed to bridge the gap between biology and technology....Photonics.com 10/25/2022Selecting the Right Optics for Ultrafast MicroscopyUltrafast lasers are being increasingly used in life science imaging techniques such as multiphoton microscopy. However, the short pulse durations and high peak powers of ultrafast lasers make...Photonics.com 1/22/2021Using LEDs to Enhance Image Quality and Cell ViabilitySince their debut over a decade ago, LEDs have had an ever increasing impact on the world of fluorescence microscopy. To appreciate this growth in popularity, Alex Gramann addresses many of the...PHOTONICS DICTIONARY+ TERMSPhotonics Dictionarylight sheet fluorescence microscopyAlso known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. In this method, a light sheet illuminates...Photonics Dictionarystructured illumination microscopyStructured illumination microscopy (SIM) is an advanced optical imaging technique used in microscopy to enhance the resolution of images beyond the diffraction limit imposed by traditional light...Photonics DictionaryphototoxicityPhototoxicity refers to the harmful effects caused by exposure to light, particularly intense or ultraviolet (UV) light, on living cells or organisms. This phenomenon is often associated with the...Photonics Dictionarystochastic optical reconstruction microscopyStochastic optical reconstruction microscopy (STORM) is a superresolution microscopy technique that enables imaging of biological specimens at resolutions beyond the diffraction limit of conventional...VIDEOSPhotonics.com 11/20/2023New Dragonfly 600 Confocal Microscope System - Andor TechnologyThe Dragonfly 600 confocal microscope system delivers outstanding multi-dimensional images from subcellular (nm) to whole organism (cm), while significantly boosting productivity. Its unrivalled...Photonics.com 11/20/2023Andor's Life Science Research SolutionsAt Andor, it matters to us that the products we develop make a real difference to our customers and contribute significantly to their research across Immunology, Microbiology, Neuroscience, Cells &...Photonics.com 11/20/2023New ZL41 Cell & Sona sCMOS - Easy, Flexible, Cost-Effective Super Resolution Microscopy - Andor TechnologyEasy and Cost-Effective Super-Resolution to ~100 nm. Andor has introduced two new highly innovative sCMOS cameras, both delivering easy and cost-effective access to super-resolution capabilities and...Photonics.com 5/2/2022Applied Scientific InstrumentationEstablished in 1990, Applied Scientific Instrumentation is a reknown American company committed to the advancement of science. ASI products have been thoroughly tested and evaluated in numerous labs...PHOTONICS BUYERS' GUIDE CATEGORIESPhase Contrast MicroscopesScanning Electron Microscopes (SEM)A scanning electron microscope is an electron microscope that uses a beam of electrons -- accelerated to high energy and focused on the sample -- to scan the sample surface, ejecting secondary...Research MicroscopesStereo MicroscopesCOMPANIESPhotonics Buyers' GuideApplied Scientific Instrumentation Inc.Applied Scientific Instrumentation, Inc. (ASI) is a company committed to the advancement of science. Our engineers and technicians have years of experience in aiding researchers with their technical...Photonics Buyers' GuideAndor TechnologyAndor Technology Ltd is a global developer and manufacturer of high-performance scientific cameras, microscopy systems and spectrographs for academic, government, and industrial applications. Founded...Photonics Buyers' GuideOptikos CorporationThe Optical Engineering Experts® Optikos designs and manufactures metrology products for measuring and assuring optical image quality; and provides optical engineering design, development,...Photonics Buyers' GuideOZ Optics LimitedEstablished in 1985, OZ Optics is a leading worldwide supplier of fiber optic components, test equipment and sensors. OZ Optics manufactures its products in three locations, Ottawa (Canada),...