Request InfoCarl Zeiss Spectroscopy GmbHZeiss has added the Elyra P.1 module to its 3-D microscopy portfolio. The system enables superresolution photoactivated localization microscopy (PALM) for endogenously expressed photoswitchable fluorescent proteins. This capability allows researchers to investigate the structural arrangement of one or multiple proteins, reveal the structure of organelles in 2-D and 3-D, and count and map molecules within a structure. In PALM, photoswitchable fluorescent molecules are sparsely activated so that only one out of many will be in its “on” state within a single point spread...See full productRelated content from Photonics MediaPRODUCTSBioPhotonics Mar/Apr 2023 IssueCell Imaging SystemThe Axiovert 5 cell imaging system from ZEISS uses artificial intelligence and automatic functions to ease daily work in the cell lab. From scientific routine and basic research to phase...Photonics.com 11/24/2021CMOS SensorThe Apx60 high-resolution CMOS sensor from Atik Cameras Ltd. is built for the industrial, scientific, and OEM sectors. The large device employs 61 MP over a 43.3-mm diagonal sensor. With no amp...Photonics Showcase April 2022 IssueMicroscope CameraThe LC35 microscope camera from Olympus Corp. provides quality brightfield images in a cost-effective package. 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LENSO will join the ZEISS Sales...Photonics.com 4/29/2022Noninvasive Imaging Method Measures Below the Diffraction LimitA label-free microscopy technique developed by researchers at the University of Graz enables noninvasive, sub-diffraction-limit imaging of nanostructures. The all-linear, optical far-field...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookSuperresolution Microscopy: An Imaging Revolution: Despite tremendous accomplishments in recent years, superresolution microscopy is a relatively young field, and confusion exists in this domain of many abbreviations. However, this makes for captivating times as superresolution microscopy opens the door to wider imaging applications.Superresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookLasers for Microscopy: Major Trends: In order for biologists, drug developers, clinical lab professionals and other scientists to fully exploit new microscopy techniques and applications, parallel developments in laser technology are often required. Laser manufacturers are responding with products optimized to match the needs of these applications.Laser development for the microscopy market continues to be driven by key trends in applications, which currently include superresolution techniques, multiphoton applications in optogenetics and...Photonics HandbookNanopositioning: A Step Ahead: It is almost a cliché among students of creativity that innovation occurs at the intersection of fields. Since nanopositioning is a discipline that has enabled swiftly evolving application arenas as diverse as materials science, genomics, photonics, defense, biophysics, and semiconductors, it’s unsurprising that its pace of innovation is nothing short of blistering in recent years.By its original definition, a nanopositioning device is a mechanism capable of repeatedly delivering motion in increments as small as one nanometer. Lately demands from industry and research have...Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best Approach: Fluorescence lifetime imaging microscopy (FLIM), which measures the spatial distribution of the fluorescence decay, can be achieved either in the time or in the frequency domain. Each approach exhibits advantages and disadvantages, depending on the type of light detector and acquisition method employed.The term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...WHITEPAPERSPhotonics.com 10/4/2022Product Development Strategies for Electro-Optical SystemsThis whitepaper looks at the unique challenges associated with optical systems by exploring two extremes, an ultra-high precision instrument, and a low-cost consumer product, and the different...Photonics.com 9/12/2022Ingenuity + Instrumentation: Creating a Novel 4D Microscopy MethodTracking particles at the micro or nanoscale is inherently difficult due to the complexity of the systems studied, as well as the technical challenges: a blend of instrument design, photonics,...Photonics.com 4/28/2023“Fingerprint” vs Handheld Raman Applications and the Different Optical Filters That Enable ThemRaman spectroscopy is a powerful non-invasive, non-contact tool capable of identifying molecular constituents of samples. Wavelength selective optical filters are used to block the dominant Rayleigh...Photonics.com 11/1/2022How Right Angle Prisms Work?How Right Angle Prisms Work? Mainly used in various optical instruments and optical imaging fields, for bending image paths or 90° turning rays. Right-angle prisms can produce left-handed images that...WEBINARSPhotonics.com 1/19/2022Next-Generation Optics Software: Trends in TechnologyPhysical optics calculation software typically provides a single solving program for Maxwell’s equations. Field solvers such as finite difference time domain (FDTD) or the finite element method...Photonics.com 8/17/2022Sub-Cellular Biology at Tissue Scales with Cleared Tissue Axially Swept Light-Sheet MicroscopyLarge-scale interdisciplinary research efforts have worked to comprehensively catalog cellular architectures in health and disease. To aid in this effort, researchers have developed a scalable...Photonics.com 3/21/2013Techniques in Biophotonic ImagingFREE WEBINAR Sponsored by: Hamamatsu & Applied Scientific Instrumentation Additional Questions & Answers from the webinar are below: Dr. Kimani C. Toussaint Jr. Quantitative...Photonics.com 2/16/2017High-Speed Imaging At and Beyond the Diffraction LimitHari Shroff, Ph.D., head of the Section on High Resolution Optical Imaging at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), will speak on his lab's latest work to develop...PHOTONICS DICTIONARY+ TERMSEDU.photonics.com 9/8/2009point spread function (PSF)In an optical system, the energy intensity distribution about the image of a point source.EDU.photonics.com 3/5/2018Light Sheet Fluorescence Microscopy (LSFM)Also known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. In this method, a light sheet illuminates...EDU.photonics.com 3/5/2018Geometrical opticsThe area of optics in which the propagation of light is described by geometrical lines (or rays) governed by Fermat's Principle. Geometrical optics is useful as long as the objects in which the light...EDU.photonics.com 3/5/2018two-photon excited fluorescenceTwo-photon excited fluorescence (TPEF) is a nonlinear optical method that allows imaging of biological cells and living tissue. The advantage of TPEF in comparison to conventional fluorescence...VIDEOSPhotonics.com 1/18/2018Supporting the Photonics Industry from the Laboratory - LIGHT MATTERS 01.2018On this month's episode of Light Matters, we take you to central Massachusetts as Worcester Polytechnic Institute and Quinsigamond Community College take on a comprehensive joint photonics laboratory...Photonics.com 1/18/2018Light Matters Extra: Taking Photonics Innovations from the Lab to the Operating Room - 01.2018In this month's Light Matters Extra, we give you an in-depth look at the relationship between researchers and scientists at the University of California Davis, and surgeons and clinicians at nearby...Photonics.com 2/21/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 9/2/2015New Frontiers of Superresolution Microscopy! - LIGHT MATTERS 09.02.2015On this week's show we'll learn about new techniques pushing superresolution microscopy EVEN FURTHER to reveal the inner lives of cells. We'll also see how light could play a role in tissue...PHOTONICS BUYERS' GUIDE CATEGORIESSuperresolution Imaging SystemsMicroscope LensesUltraviolet MicroscopesAn ultraviolet microscope is a microscope used either to detect selective absorption of various wavelengths by the specimen or to achieve increased resolution by virtue of the short wavelength of...Conical LensesConical lenses are lenses with a surface that is a cone instead of the usual sphere.COMPANIESPhotonics Buyers' GuideCarl Zeiss Spectroscopy GmbHCarl Zeiss Spectroscopy develops and produces optical gratings, optical modules, and spectrometer systems of highest quality, superior optical performance, robust design and fast analysis. We...Photonics Buyers' GuideLaCroix Precision OpticsOptics that Defend, Build, Cure and Discover The LaCroix name is synonymous with quality precision optics. Since 1947, three generations of family leadership have placed LaCroix Precision Optics...Photonics Buyers' GuideReynard CorporationReynard Corporation has been a premier supplier of custom optics and thin-film coatings to a global customer base since 1984. Reynard focuses on manufacturing the highest quality products with...Photonics Buyers' GuideMLD Technologies LLCExperts In Thin-film Coating Design We practice a design-before-quote approach to help customers refine specifications and minimize technical risk. We understand how coated optical elements...