Request InfoLeica Microsystems GmbHWETZLAR, Germany, July 26, 2010 — Resolution and contrast are important for fluorescence applications in wide-field microscopy. Undesired haze effects that reduce contrast can be minimized by using the smart principle of structured illumination. The result is fluorescence images with good contrast, high axial resolution and ultrasharp 2- and 3-D sections of the specimen. Intelligent Structured Illumination Microscopy from Leica Microsystems GmbH uses the proven OptiGrid technique. Working in harmony with the company’s high-quality optics, the aperture diaphragm integrated with the fluorescence light path also...See full productRelated content from Photonics MediaPRODUCTSBioPhotonics Mar/Apr 2022 IssueDigital Neurosurgery MicroscopeThe ARveo 8 digital visualization neurosurgery microscope from Leica Microsystems features fast processing speeds for augmented reality visualization. The device benefits an entire...Photonics.com 11/24/2021CMOS SensorThe Apx60 high-resolution CMOS sensor from Atik Cameras Ltd. is built for the industrial, scientific, and OEM sectors. The large device employs 61 MP over a 43.3-mm diagonal sensor. With no amp...BioPhotonics Sep/Oct 2023 IssueAI-Powered Microscope SoftwareLeica Microsystems’ Aivia 12 software provides AI-powered image analysis. It incorporates the Cellpose deep learning model to tackle dense neuron images, improving soma detection by as much as...BioPhotonics Jul/Aug 2023 IssueCooled sCMOS CamerasXimea’s MJ042MR-GP-P11-BSI-UV model was added to its portfolio of scientific cameras. It’s equipped with a Gpixel PulSar sCMOS sensor that is combined with Peltier cooling and USB3...ARTICLESBioPhotonics May/Jun 2023 IssueModule Uses Single-photon Microscopy to Track Cellular ActivityBrightEyes-TTM, an open-source time-tagging module (TTM) developed at the Italian Institute of Technology (IIT), enables scientists to observe the dynamic processes of molecules inside living cells...Photonics.com 12/31/2021Optimized Optical Tweezers Look Before GrabbingOptical tweezers working in tandem will one day be able to grasp and manipulate cell clusters with a high level of dexterity, according to research from the University of Freiburg. The work would...BioPhotonics Nov/Dec 2021 IssueMicroscopy Method Enables Deep In Vivo Brain ImagingA method developed by the Prevedel Group at the European Molecular Biology Laboratory (EMBL) allows neuroscientists to observe live neurons deep within the brain — or any other cell hidden...Photonics.com 8/15/2023Light-Triggered Particles Deliver Photoimmunotherapy for CancerA research group from Japan Advanced Institute of Science and Technology (JAIST) developed light-activatable, liquid metal (LM) nanoparticles for cancer diagnosis and treatment via...PHOTONICS HANDBOOK ARTICLESPhotonics HandbookSuperresolution Microscopy: An Imaging Revolution: Despite tremendous accomplishments in recent years, superresolution microscopy is a relatively young field, and confusion exists in this domain of many abbreviations. However, this makes for captivating times as superresolution microscopy opens the door to wider imaging applications.Superresolution optical microscopy, for which the Nobel Prize was awarded to Eric Betzig, Stefan Hell, and William Moerner in 2014, has been one of the most momentous developments in the life...Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best Approach: Fluorescence lifetime imaging microscopy (FLIM), which measures the spatial distribution of the fluorescence decay, can be achieved either in the time or in the frequency domain. Each approach exhibits advantages and disadvantages, depending on the type of light detector and acquisition method employed.The term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookMicroscopy Illumination: Considering Nonlaser Light Sources: Metal halide and LED light sources are changing the illumination landscape in microscopy. Brighter, easier to use and growing in application, they are driving new options in fluorescence, conventional bright-field and other contrast techniques.As recently as five years ago, shopping for a microscope light source was fairly straightforward. For routine applications, it was tungsten halogen, typically 100 W, while for fluorescence, it was an...Photonics HandbookLasers for Microscopy: Major Trends: In order for biologists, drug developers, clinical lab professionals and other scientists to fully exploit new microscopy techniques and applications, parallel developments in laser technology are often required. Laser manufacturers are responding with products optimized to match the needs of these applications.Laser development for the microscopy market continues to be driven by key trends in applications, which currently include superresolution techniques, multiphoton applications in optogenetics and...WHITEPAPERSPhotonics.com 10/4/2022Product Development Strategies for Electro-Optical SystemsThis whitepaper looks at the unique challenges associated with optical systems by exploring two extremes, an ultra-high precision instrument, and a low-cost consumer product, and the different...Photonics.com 4/20/2023Is a DIY Microscope for You?For some advanced microscopy and nanoscopy techniques it becomes necessary to modify existing instrumentation or build an instrument from scratch. This article helps readers determine whether a...Photonics.com 9/27/2023Raman SpectroscopyTo achieve accurate and precise Raman measurements, optical filters play a crucial role in enhancing signal-to-noise ratio, and reducing background interference. This white paper explores the...Photonics.com 12/8/2022Sub 50 Femtosecond Pulse Lasers for Gentler Multiphoton MicroscopyFinding the ideal ultra-fast laser source for a multiphoton imaging setup is not trivial. It is a fine balance between peak power, pulse energy and laser wavelength. 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Toussaint Jr. Quantitative...PHOTONICS DICTIONARY+ TERMSEDU.photonics.com 6/30/2017wide-field fluorescence microscopyWide-field fluorescence microscopy uses either naturally occurring structures or staining with fluorescent tags that are activated by specific wavelengths of light and then emits a different...EDU.photonics.com 9/8/2009erecting systemLenses or prisms that serve to erect the image; i.e., to bring the image upright after it has been inverted by the objective.EDU.photonics.com 9/8/2009wide-field eyepieceAn eyepiece or magnifier capable of covering a field of view that is greater than 50°.EDU.photonics.com 9/8/2009fiber-linked array image formatter (FLAIR)A wide-field multiobject spectroscopy system used in astronomy, in which a bundle of low-loss optical fibers positioned on the target images is rearranged at its other end into a linear array along...VIDEOSPhotonics.com 8/10/2021Short Introduction of CODIXX, Winner of the AURA foreign trade award 2019 - CODIXXCODIXX is a corporation under German Law, established in September 1998. After a period of research and development CODIXX started the production of a new family of dichroic glass polarizers in 2002....Photonics.com 2/21/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 6/20/2023LASEROPTIK Blockbuster 4KWelcome to the movies and inside the home of laser optics and coatings! Get an impression of our daily routine and enjoy our thin films film stars ...Photonics.com 8/24/2022Ramacle® Software Highlight: Fast Mapping - Edinburgh InstrumentsThis Software Highlight focuses on Fast Mapping in our Ramacle software. 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LtdOptolong Optics Co., Ltd is a manufacturer of fluorescence filters and astronomy filters. We also offer other interference filters such as UV filters, visible filters and near-infrared filters,...Photonics Buyers' GuideFresnel Technologies Inc.Fresnel Technologies Inc. is an expert manufacturer of molded plastic optics, including Fresnel lenses and related optical components, as well as infrared transmitting materials and optics made from...