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Light-Sheet Microscope Automatically Adjusts to Optimize Image Quality

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A light-sheet microscope has been developed that can automatically adapt to the dynamic optical conditions of large living specimens. The smart microscope combines a novel hardware design with a software system that can analyze a specimen continuously and automatically adjust the settings to maximize image quality. Called the AutoPilot framework, this development could enable long-term adaptive imaging of entire developing embryos and improve the resolution of light-sheet microscopes up to five-fold. Researchers from the Janelia Research Campus at Howard Hughes Medical Institute, the...Read full article

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    Published: November 2016
    Glossary
    fluorescence microscopy
    Fluorescence microscopy is a specialized optical imaging technique used in biology, chemistry, and materials science to visualize and study specimens that exhibit fluorescence. Fluorescence is the phenomenon where a substance absorbs light at one wavelength and emits light at a longer wavelength. In fluorescence microscopy, fluorescent dyes or proteins are used to label specific structures or molecules within a sample. The basic principles of fluorescence microscopy involve illuminating the...
    Research & TechnologyAmericasEuropeBiophotonicsImagingMicroscopylight sheet microscopyfluorescence microscopyTech Pulse

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