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Fluorescence Lifetime Imaging Microscopy Provides Molecular Insights in Neurology Fluorescence Lifetime Imaging Microscopy Provides Molecular Insights in Neurology
Fluorescence lifetime imaging microscopy (FLIM) is rapidly becoming a transformative tool in neurology, enabling the visualization of molecular and metabolic processes in living brain tissue and other samples with unprecedented detail. FLIM provides contrast based on the local biochemical environment, independent of fluorophore concentration or photobleaching, by measuring the excited-state lifetimes of intrinsic or extrinsic fluorophores. FLIM is used in both current and emerging applications
BioPhotonics, Nov/Dec 2025
Functional Near-Infrared Spectroscopy Targets Changes in Brain Metabolism Functional Near-Infrared Spectroscopy Targets Changes in Brain Metabolism
Functional near-infrared spectroscopy (fNIRS) was once confined to stationary, wired systems that limited studies to controlled laboratory environments. But today’s devices using this technology are lighter, wireless, and designed for true...
BioPhotonics, Nov/Dec 2025
Multiphoton Microscopy Provides a Deeper View of the Aging Brain Multiphoton Microscopy Provides a Deeper View of the Aging Brain
Because deep-brain structures are key to how the nervous system communicates and maintains healthy function, understanding them is crucial for studying neurovascular dynamics, age-related changes, and neurodegenerative diseases. Multiphoton...
BioPhotonics, Nov/Dec 2025
Fiber Optics Clarifies the View of Neural Activity Fiber Optics Clarifies the View of Neural Activity
Optical fiber was once relegated to simple light delivery and collection in medical instruments, often for exploratory procedures. Today, this fiber winds its way into all manner of instrumentation in the laboratory and clinic, capturing health data...
BioPhotonics, Nov/Dec 2025
Raman and Laser-Induced Breakdown Spectroscopy Augment Chemical Analysis Raman and Laser-Induced Breakdown Spectroscopy Augment Chemical Analysis
Raman spectroscopy and laser-induced breakdown spectroscopy (LIBS) are two laser-based optical methods that provide complementary insights into the chemical composition of materials. Raman spectroscopy identifies molecular structures by detecting...
BioPhotonics, Sep/Oct 2025
Smartphone-Based NIRS Imaging Classifies Wounds Smartphone-Based NIRS Imaging Classifies Wounds
Diabetes mellitus affects >32.2 million people in the U.S. and an additional 12.5% of the U.S. population is prediabetic1. One in three people with diabetes is affected by diabetic foot ulcers (DFUs) during their lifetime2. If this condition is...
BioPhotonics, Sep/Oct 2025
Foveation and Spectral Imaging: Nature-Inspired Data Reduction for Efficient Devices Foveation and Spectral Imaging: Nature-Inspired Data Reduction for Efficient Devices
Hyperspectral imaging (HSI) holds great promise for medicine as it matures into a practical technology. The fusion of imaging methods that spatially resolve light energy passing through an opening with methods that spectrally resolve the light can...
BioPhotonics, Sep/Oct 2025
Fluorescence Microscopy and Microfluidics Intersect for Biological Discovery Fluorescence Microscopy and Microfluidics Intersect for Biological Discovery
Microfluidics has transformed from a niche technology into a fundamental tool for biological experimentation during the last decade. When coupled with wide-field fluorescence microscopy, it enables the observation of biological systems at both the...
BioPhotonics, Sep/Oct 2025
Miniaturized photonic components drive medical intervention Miniaturized photonic components drive medical intervention
The miniaturization of components used in medical imaging has facilitated a range of groundbreaking diagnostics and therapeutics in modern health care. These imaging systems help to create detailed visual representations of the interior of tissues...
BioPhotonics, Jul/Aug 2025
Photonic Integrated Circuits Enable High-Speed OCT Imaging of the Eye Photonic Integrated Circuits Enable High-Speed OCT Imaging of the Eye
In the U.S., eye diseases and vision problems are widespread, with diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy affecting millions of people. The NIH estimates that by 2030, 5 million Americans will...
BioPhotonics, Jul/Aug 2025
Laser-based spectroscopy finds diagnostic answers in breath Laser-based spectroscopy finds diagnostic answers in breath
Breath analysis has emerged as a promising noninvasive diagnostic tool for detecting a wide range of diseases by identifying biomarkers in exhaled gases. And advanced optoelectronic systems, particularly those based on mid-infrared (MIR) laser...
BioPhotonics, Jul/Aug 2025
Organ-on-a-Chip Technologies Shape the Future of Biotech Functionality Organ-on-a-Chip Technologies Shape the Future of Biotech Functionality
Offering compactness, efficiency, and automation in a single chip-size platform, lab-on-a-chip (LoC) technology has achieved remarkable progress during the last three decades. LoC systems miniaturize and integrate the essential steps of an...
Photonics Spectra, September 2025
Lasers Drive Production of Radioisotopes for Medical Diagnostics and Therapy Lasers Drive Production of Radioisotopes for Medical Diagnostics and Therapy
A radioisotope is an unstable atomic nucleus that undergoes radioactive decay, or more simply, a change in nuclear structure with the simultaneous emission of radiation. Radioisotopes can now be generated using lasers, which could help meet the...
BioPhotonics, May/Jun 2025
Advancements in Shortwave Infrared Technology Drive Medical Imaging Advancements in Shortwave Infrared Technology Drive Medical Imaging
Shortwave infrared (SWIR) imaging, which captures light that is invisible to the human eye, is transforming the effectiveness of systems in many fields, such as medical analysis and industrial inspection, by enabling high-contrast imaging beyond the...
BioPhotonics, May/Jun 2025
Feeling with Photons: Brillouin Microscopy Advances Biomaterials Research Feeling with Photons: Brillouin Microscopy Advances Biomaterials Research
Brillouin microscopy was first developed for materials science fields that focus on the examination of condensed matter to assess properties such as elasticity and viscosity. The introduction of Brillouin microscopy to the biological sciences has...
BioPhotonics, May/Jun 2025
Compact Transmission-Based Raman Spectrometers Provide Swift, Noninvasive Diagnostics Compact Transmission-Based Raman Spectrometers Provide Swift, Noninvasive Diagnostics
Raman spectroscopy, a method that decodes molecular signatures by examining light’s inelastic scattering, has long been a cornerstone of analytical science, revealing everything from biochemical markers in tissues to contaminants in food....
BioPhotonics, May/Jun 2025
Simplifying Flow Cytometry Through Panel Design Simplifying Flow Cytometry Through Panel Design
Flow cytometry is an analytical technique that enables rapid, high-resolution analysis of diverse cell populations at high throughput. In fields such as immunology, oncology, and drug discovery, the ability to identify different cell types from a...
BioPhotonics, Mar/Apr 2025
Dynamic Light-Scattering Method Confirms Alzheimer’s Disease Study Results Dynamic Light-Scattering Method Confirms Alzheimer’s Disease Study Results
Alzheimer’s is a slowly progressing disease caused by physical changes in the brain, resulting in the loss of mental abilities and memory. Unfortunately, a simple clinical test does not exist to diagnose the condition in a living patient....
BioPhotonics, Mar/Apr 2025
Machine Learning Boosts Speed and Quality of Second-Harmonic Generation Microscopy Machine Learning Boosts Speed and Quality of Second-Harmonic Generation Microscopy
In biological research, the visualization of tissue structures is critical for understanding their function as well as in tracking the progression of diseases in various stages. Second-harmonic generation (SHG) and polarization-resolved SHG (P-SHG)...
BioPhotonics, Mar/Apr 2025
The Evolution of Fluorescence Illumination Is Refining Medical and Research Applications The Evolution of Fluorescence Illumination Is Refining Medical and Research Applications
Innovations in biomedical illumination technology are transforming various aspects of medical procedures, imaging techniques, and therapeutic interventions. Improved illumination enables surgeons to perform complex procedures with greater precision...
BioPhotonics, Mar/Apr 2025
SPIE Names 2025 Prism Award Winners SPIE Names 2025 Prism Award Winners
SPIE, the international society for optics and photonics, recognized the top innovations in new optics and photonics products at the 2025 Prism Awards held at Photonics West on Jan. 29. The gala event marked the Prism Awards’ 17th anniversary....
BioPhotonics, Mar/Apr 2025
Fluorescence LED Illumination Systems Can Be Customized for Life Sciences Applications Fluorescence LED Illumination Systems Can Be Customized for Life Sciences Applications
Automation is a widespread trend across the life sciences, maximizing throughput and efficiency in applications such as drug development and clinical testing. For example, high-throughput screening — often enhanced by advanced illumination...
BioPhotonics, Jan/Feb 2025
Tapping the Terahertz: Capturing Clues in Tissue Hydration Tapping the Terahertz: Capturing Clues in Tissue Hydration
Due to its low photon energy and ability to penetrate certain types of materials, terahertz imaging holds a great deal of promise for the identification of key biological indicators — particularly those inherent in the skin — in life...
BioPhotonics, Jan/Feb 2025
LEDs and Multi-Bandpass Filters Work in Tandem to Transform Fluorescence Instrumentation LEDs and Multi-Bandpass Filters Work in Tandem to Transform Fluorescence Instrumentation
Fluorescence stands as a cornerstone technology in the realm of bioanalysis. Fluorescence is one of the most sensitive spectroscopic quantification techniques, and fluorescence microscopy methods, including wide-field and confocal microscopy, enable...
BioPhotonics, Jan/Feb 2025
NIR Spectroscopy Provides a Chemical Perspective on the Composition of Teeth NIR Spectroscopy Provides a Chemical Perspective on the Composition of Teeth
While dentistry has become increasingly sophisticated, uncertainties still exist in the diagnosis and treatment of dental conditions that are left to the discretion of the practitioner. Part of the reason for this uncertainty is that the composition...
BioPhotonics, Jan/Feb 2025
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