Algorithm Targets Microscope Resolution
BOSTON, Nov. 16, 2023 — Scientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the microscope’s point spread function, is one approach. Deconvolution, however, can lead to noise-amplification artifacts between the sample and the image, decreasing the image resolution. To prevent artifacts, researchers at Boston University developed an image deblurring algorithm that sharpens images