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medical News
Label-Free Microscopy Analyzes Dynamics of Cell Membranes
URBANA, Ill., June 6, 2018 — A new live cell imaging technique will enable researchers to observe the formation and growth of cell membrane focal adhesions. Examining focal adhesions — cell membrane components that regulate adhesion and migration — is one of the keys to understanding how a cell proliferates, differentiates, and migrates. Photonic resonator outcoupler microscopy (PROM) is a label-free approach for dynamic, long-term, quantitative imaging of cell-surface interactions. PROM utilizes a
Graphene Biointerface Optically Controls Heart Cells
SANTA BARBARA, Calif., May 29, 2018 — Researchers have developed a technique that allows them to speed up or slow down human heart cells, on command, by shining a light on the cells and varying the light intensity. The optical stimulation platform does not require genetic modification...
NIH Researchers Merge Microscopy Techniques for Faster Images
BETHESDA, Md., May 17, 2018 — To create sharper images more quickly, researchers blended instant structured illumination microscopy (iSIM) with total internal reflection fluorescence microscopy (TIRFM). The new technique, called instant TIRF-SIM, allows researchers to observe...
Engineered Glass Slide Enables Microscopic Thermal Mapping
BUFFALO, N.Y., May 15, 2018 — Using a coating of an optical exceptional point structure, researchers demonstrated a multifunctional microscope slide that supports real-time monitoring and mapping of temperature distribution and heat transport, in addition to conventional...
Sensing Chip Uses Raman Spectroscopy to Detect Cocaine in Minutes
BUFFALO, N.Y., May 7, 2018 — A chemical sensing chip, developed for use with surface-enhanced Raman spectroscopy (SERS), has demonstrated the ability to detect the chemical fingerprint of cocaine in biological samples. In the future, the technology could be used to detect the...
Optogenetic Tool Controls Voltage-Gated Calcium Channels
COLLEGE STATION, Texas, May 2, 2018 — An optogenetic tool has been developed for controlling voltage-gated calcium (CaV) channels to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. The tool, called optoRGK, provides a way to interrogate the...
Chemical Device Uses Light to Reprogram Gene Expression
COLLEGE STATION, Texas, May 1, 2018 — Researchers at Texas A&M have developed a chemical or light-inducible transcriptional reprogramming device to illuminate the functions of genes during different biological processes, using calcium and light. The CaRROT system (calcium-responsive...
Light-Based Approach Manages Chronic Neuropathic Pain
ROME, April 27, 2018 — Researchers have developed a light-based method that could be used to manage neuropathic pain. The technique was tested in mice. Researchers from the European Molecular Biology Laboratory (EMBL) Rome identified a specific population of nerve cells...
Tiny Fiber Optic Probe Senses Body Temps, Performs OCT Imaging
ADELAIDE, Australia, April 16, 2018 — A miniaturized fiber optic probe has been invented that can simultaneously measure body temperature and take images deep inside the body. The single-fiber-based image and sensing probe uses an OCT lens fabricated at the distal end of a double-clad...
Plant Protein Powers Red Light-Activated Switch for Animal Cells
LA JOLLA, Calif., April 11, 2018 — An optogenetic switch activated by red and far-red light has been designed and tested in animal cells. The light-activated switch, which does not require the addition of sensing molecules from outside the cells, could be used to turn genes on and...
Renishaw Partners with Cardiff University to Develop Removable 3D-Printed Dentures
CARDIFF, Wales, April 11, 2018 — Precision measurement technology developer Renishaw Inc. is working with Cardiff University Dental Hospital (CUDH) to develop 3D-printed Cobalt Chrome (CoCr) removable partial dentures (RPDs). Currently, RPDs are produced in wax or digitally...
Technique to Suppress Photobleaching Increases Imaging Window
OKINAWA, Japan, April 10, 2018 — To better understand how proteins move and interact within the cell membrane, an imaging method called live-cell single fluorescent-molecule imaging (SFMI) can be used to tag each protein in the membrane individually with fluorescent markers. The...
Microsensor Could Help Individualize Dialysis Treatment
EINDHOVEN, Netherlands, April 9, 2018 — A new microsensor could make it possible to directly monitor and adjust the composition of kidney dialysis fluid (dialysate) — an important step toward customizing dialysis to the individual patient. The sensor provides a way to monitor the...
Optically Heated Nanotweezers Manipulate Materials at Nanoscale
AUSTIN, Texas, April 9, 2018 — Opto-thermoelectric nanotweezers (OTENTs) have been developed that use light at the nanoscale to manipulate metal nanoparticles in a wide range of materials, sizes, and shapes, with single-particle resolution. OTENTs could open new possibilities for...
NIR Chemical Imaging Can Help Ensure Safety in Pharma Manufacturing
QUEBEC CITY, April 2, 2018 — Researchers evaluated the ability of NIR chemical imaging (NIR CI) to monitor the concentration of pharmaceutical ingredients in tableting powder over a wide area. Results showed that NIR CI-based predictions of concentration could potentially be...
Confocal Laser Endomicroscopy Uncovers Previously Unknown Organ
NEW YORK, April 2, 2018 — Using novel imaging technology called probe-based confocal laser endomicroscopy, researchers have identified a previously unknown feature of human anatomy which could have implications for the function of organs, tissues and diseases. The technology...
Point-of-Care Device Could Improve Thyroid Cancer Screening
BARCELONA, Spain, March 21, 2018 — A team of international researchers developed a point-of-care device that could enable consistent and cost-effective screening for thyroid nodules. This novel device builds on the current ultrasound standard with a hybrid optics/ultrasound probe....
Optical Tool Uses Fluorescence to Detect Metabolic Changes
MEDFORD, Mass., March 12, 2018 — An optical tool that can read metabolism at subcellular resolution could be used to identify specific metabolic signatures that could be indicative of disease. The method detects functional and structural metabolic biomarkers noninvasively using...
Microscope Provides Precise 3D Imaging of Thick Mammalian Cells
STANFORD, Calif., March 5, 2018 — A new microscope produces 3D nanoscale images of mammalian cells in their entirety. Because the axial positions of the single emitters are encoded in the shape of each single-molecule image rather than in the position or thickness of the light...
Nanophotonic Sensors Monitor Processes in Living Cells
OKINAWA, Japan, Feb. 27, 2018 — A large-scale biosensor developed using nanoplasmonic material is able to accommodate a large number of cells on a single substrate and monitor cell proliferation in real time. The nanoplasmonic material allows for long-term cell survival and...
A New Use for Deep Learning — Hologram Reconstruction
LOS ANGELES, Feb. 26, 2018 — Researchers have used a deep learning-based, computational approach to reconstruct a hologram and form a microscopic image of an object. This deep learning-based technique rapidly eliminates twin-image and self-interference-related artifacts using...
Nanocarbon Shows Promise for Fluorescent Bioimaging
NAGOYA, Japan, Feb. 22, 2018 — An international team from Nagoya University and Boston College has developed a flexible, water-soluble warped nanographene molecule that is biocompatible. The molecule was also found to induce cell death when exposed to light. The new molecule...
Tomography System Could Help Determine Who Will Respond Best to Chemo
NEW YORK, Feb. 20, 2018 — A new optical imaging system uses red and NIR light to identify breast cancer patients who could benefit most from chemotherapy. The dynamic diffuse optical tomography system could be able to predict response to chemotherapy as early as two weeks...
Spectroscopy Explores Photoinduced Reactions in Anticancer Drug
COVENTRY, England, Feb. 20, 2018 — Using IR spectroscopy researchers have gained fresh insight into how a platinum-based chemotherapy drug candidate functions when activated by light. Completely inactive and non-toxic in the dark, the treatment can be targeted to cancerous areas and...
Far-UVC Light Could Safely Limit Spread of Flu, Other Airborne Viruses
NEW YORK, Feb. 12, 2018 — Continuous low doses of far-UVC light have been shown to kill airborne flu viruses without harming human tissue. Far-UVC light could offer a low-cost solution to controlling airborne microbial diseases in indoor public spaces. <br A study...
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