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optogenetics News
Imaging Method Lights up Brain Oxygenation
ROCHESTER, N.Y., April 11, 2024 — Researchers at the University of Rochester and University of Copenhagen’s Center for Translational Neuromedicine developed a bioluminescence imaging technique that tracks the movement of oxygen in mice brains to reveal the level of oxygen present in the mice’s cortical tissue under different physiological conditions. As more oxygen enters the brain, the luminescence grows brighter. The method can be easily replicated by other labs and is expected to enable the forms of brain
Microprism-Mediated Calcium Imaging Reveals Neural Dynamics Over Time
SEATTLE, April 10, 2024 — An approach to deep brain imaging developed at the University of Washington uses microprisms to provide stable tracking of neuronal activity over a large field of view. According to the research team, the microprism technique is a significant...
Whole-Brain Big Data Processing Enables VR via Optogenetic Control
SHANGHAI, March 28, 2024 — The massive amount of data processing required to image whole-brain activity makes real-time analysis and closed-loop research into neuronal dynamics extremely challenging. Yet, real-time analysis of large-scale brain imaging is crucial to...
Researchers Develop High-Precision Dual-Color Optogenetic Brain Probe
AMHERST, Mass., Dec. 26, 2023 — Optogenetics promises to manipulate brain circuitry by exciting or inhibiting neurons with different wavelengths of light. Until now, neural probes have largely been limited to single colors, only capable of either excitation or inhibition. Probes...
Two-Photon Holographic Mesoscope Probes Activity Across Large Brain Regions
BERKELEY, Calif., Dec.18, 2023 — Recent advancements in two-photon (2P) mesoscopes have extended the field of view (FOV) for deep brain imaging, making it possible to image brain regions as large as 25 mm2. Until now, though, mesoscopes could only measure neural signals; they could...
Light-Activated Tool Controls Protein Bonds and Tracks Cell Adhesion
TAMPERE, Finland, Nov. 20, 2023 — Optical tools can be used to activate biological functions, but with current methods the effects are slow to appear, and sustained effects require continuous light activation. As a result, these light-activation tools provide limited control of fast...
Flexible Optogenetic Tool Blocks Pain, Not Movement
CAMBRIDGE, Mass., Oct. 20, 2023 — Engineers at MIT have developed soft and implantable fibers that can deliver light to major nerves through the body. When these nerves are genetically manipulated to respond to light, the fibers can send pulses of light to the nerves to inhibit...
Jenoptik Names Director of Corporate Identity, Communications; Ray Therapeutics Adds CDO: People in the News: 08/23/2023
JENA, Germany — Jenoptik named Sabine Klisch director of corporate identity and communications. Most recently, Klisch served as vice president of global marketing at MOSTLY AI, a startup in the field of AI-generated synthetic data based in Vienna. She spent most of...
Optogenetics Reveals Relationship Between Brain and Gut Health
CAMBRIDGE, Mass., June 28, 2023 — The brain-gut connection is known to influence hunger and mood, and it has also been associated with neurological and other disorders. To explore the signaling that occurs between these two organs, scientists at MIT integrated light sources, thermal...
Optogenetic Light Source Transmits Information Between Neurons
BARCELONA, Spain, April 11, 2023 — Researchers at The Institute of Photonic Sciences (ICFO) demonstrated that photons, acting as neurotransmitters, can enable communication between neurons. The researchers developed an all-optogenetic, synaptic transmission system that enabled...
Optogenetic Tools Use Blue Light to Restore Cell Function
CINCINNATI, Aug. 22, 2022 — Researchers from the University of Cincinnati (UC), the University of Illinois Urbana-Champaign (UI), and the University at Buffalo (UB) used an optogenetic technique to bring together mitochondria and lysosomes in human stem cells, to revitalize...
Fiber Photometry Manages, Records Brain Activity at Same Time
BEIJING, July 12, 2022 — Researchers at Tsinghua University and Huazhong University of Science and Technology have developed an all-fiber-transmission photometry system that permits optogenetic manipulation and multicolor recording of neuronal activities and...
Optogenetics Tool Brings Dynamics of Cellular and Tissue Mechanics to Light
OKAZAKI, Japan, Jan. 10, 2022 — A research team at the National Institute for Basic Biology (NIBB) developed an optogenetic tool that can reduce cellular contractile force to better understand how contractile forces generated by cells — those that affect an array of...
Enhancing Lanthanide-Doped Nanocrystal Upconversion Luminescence Could Improve Bioimaging, Displays
SINGAPORE, Oct. 11, 2021 — At the National University of Singapore (NUS), researchers amplified upconversion luminescence in protein-size lanthanide-doped nanocrystals. The group reconstructed the surface of the crystal to prevent surface-associated energy loss. Tests showed...
Researchers Control Brain States Via Photoswitchable Molecule
BARCELONA, Spain, July 6, 2021 — A team of scientists in Spain has directly photomodulated brain-state transitions in vivo using a photoswitchable molecule that was developed previously by researchers at the Institute for Bioengineering of Catalonia (IBEC). By applying a...
Organic Optogenetics Tool Shines Light on Brain Communication
REHOVOT, Israel, May 25, 2021 — Light-sensing proteins called rhodopsins are used in optogenetics to control neuronal activity, but existing rhodopsins can have low efficacy, especially when they are used to control synaptic activity between neurons. A mosquito-derived rhodopsin...
Laser Technology Enhances and Expands the Medical Toolkit
Apr 29, 2021 — Medical lasers have been used for decades in surgical contexts. In recent years, the development of compact, easy-to-use, and often self-contained modules has opened doors for new or enhanced procedures in ophthalmology, dentistry, dermatology, and...
Optical Tweezing Inspires Nanoscopic Trapping Method
SYDNEY, March 9, 2021 — Researchers from the University of Technology Sydney (UTS) have deployed the existing principles of optical tweezer technology, which enables the manipulation and assemblage of nanoparticles, as a base for a technique that allows them to manipulate...
Optogenetics Approach Delivers Precision Necessary to Study Bacteria in the Gut
HOUSTON, Jan. 8, 2021, — Researchers in Texas have succeeded in effectively turning gut bacteria inside the intestines of worms “on” and “off” by applying different colors of light, via an optogenetic control mechanism. The work helped the research...
Electronic, Light-Powered Chip Delivers Smarter AI
MELBOURNE, Australia, Nov. 19, 2020 — A chip that brings together imaging, processing, machine learning, and memory is enhancing artificial intelligence by imitating the way the human brain processes visual information. The device is inspired by optogenetics; the biotechnological tool...
Recently Discovered Protein Family Could Find Role in Optogenetics
MOSCOW, April 7, 2020 — Researchers from the Moscow Institute of Physics and Technology (MIPT), working with colleagues in Spain, France, and Germany, have determined and analyzed the high-resolution structure of a protein from the recently discovered heliorhodopsin...
Optogenetic Control of Protein Speeds ALS Symptoms in Zebrafish
MISHIMA, Japan, March 3, 2020 — A joint research group in Japan reproduced amyotrophic lateral sclerosis (ALS) symptoms in zebrafish by remotely controlling a disease-associated protein molecule with light. In ALS, motor neurons progressively degenerate and accumulate inclusions...
2-Photon Microscopy Shows Learning Involves Various Areas of Brain
BALTIMORE, Jan. 8, 2020 — To explore how learning and memory-building take place in the brain, scientists at Johns Hopkins University School of Medicine used a laser-assisted imaging tool to monitor and measure levels of AMPAR molecules, which help send messages between...
Researchers Aim to Build Light-Controlled Tissue Scaffolds for Cell Regeneration
AARHUS, Denmark, Dec. 19, 2019 — Researchers at Aarhus University are exploring a method of regenerating brain and heart cells using light. Their technique uses water-based nanofibers coated with organic photovoltaic nanomaterials to create light-controlled neural-stimulating...
Researchers Engineer Light-Activated Cells for Treating Diabetes
MEDFORD, Mass., Nov. 5, 2019 — Tufts University researchers have shown that glucose levels can be controlled in a mouse model of diabetes through optogenetics. When exposed to light, engineered pancreatic beta cells transplanted into diabetic mice produced more than two to three...
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April 2024
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