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optogenetics News
Light-Based Approach Manages Chronic Neuropathic Pain
ROME, April 27, 2018 — Researchers have developed a light-based method that could be used to manage neuropathic pain. The technique was tested in mice. Researchers from the European Molecular Biology Laboratory (EMBL) Rome identified a specific population of nerve cells in the skin that are responsible for sensitivity to gentle touch. These are also the cells that cause severe pain in neuropathic patients. The research team developed a light-sensitive chemical that selectively binds to this type of nerve cell.
Plant Protein Powers Red Light-Activated Switch for Animal Cells
LA JOLLA, Calif., April 11, 2018 — An optogenetic switch activated by red and far-red light has been designed and tested in animal cells. The light-activated switch, which does not require the addition of sensing molecules from outside the cells, could be used to turn genes on and...
F-VLEDs Reduce Heat Generation, Opening Way for Biomedical Applications
DAEJEON, South Korea, Feb. 5, 2018 — Flexible vertical micro-LEDs (f-VLEDs) have been developed using anisotropic conductive film (ACF)-based transfer and interconnection technology. Thermal reliability and lifetime was improved by reducing heat generation within the thin film LEDs....
Phototherapy Treats Metastatic Disease Using Light-Sensitive Drugs
ST. LOUIS, Jan. 30, 2018 — A new study could expand the use of phototherapy for treating metastatic disease. Researchers have demonstrated the treatment of disseminated cancer by delivering photoactivatable drugs within tissues and inside cells in vivo. Light emitted as part...
The Most Wonderful Time of the Year (Video)
Jan 9, 2018 — Three conferences and two exhibitions make SPIE Photonics West the world’s largest annual event in the industry. From plenary presentations to networking opportunities, this show offers an expansive, comprehensive look at the photonics...
Ultrafast Pulses Coherently Control Function in a Living Cell
CHAMPAIGN, Ill., Nov. 17, 2017 — Researchers have used light to excite a light-sensitive channel in the membrane of optogenetic mouse neurons. When the channels were excited, they allowed ions through, which caused the neurons to fire. The researchers say the same technique could...
Photonics West Brings Together Industry’s Best, Brightest
Nov 1, 2017 — With three conferences — BiOS, LASE and OPTO — and two exhibitions, SPIE Photonics West is the world’s largest annual event for the photonics, laser and biomedical optics industries. And it’s just around the corner —...
Label-Free Imaging Maps Brain Changes in Alzheimer's Mouse Model
WUHAN, China, Oct. 20, 2017 — An imaging system called cryo-micro-optical sectioning tomography (cryo-MOST) could help speed new drug development for Alzheimer’s disease by offering a better way to monitor the brain changes indicative of Alzheimer's in mouse models....
Scientists Fine-Tune Process for Making Thin Films from DNA
SEOUL, South Korea, Oct. 13, 2017 — In order to further investigate the optical properties of a DNA-based lipid complex that is widely used in current DNA thin film research, researchers developed a refinement process to minimize the relative bound water content and control binding of...
Optogenetics Used to Control Interorganellar Communication
COLLEGE STATION, Texas, Sept. 6, 2017 — Researchers are using optogenetics to tune communication between organelles within living cells. The optogenetics tools are being used to control the proteins that form the bridge between organelles, and to govern the length of the bridge at the...
Flat Microscope to be Used in Implantable Neural Interface
HOUSTON, Aug. 3, 2017 — A prototype of a flat microscope, called FlatScope, has been developed as part of the Defense Advanced Research Projects Agency’s (DARPA’s) Neural Engineering System Design (NESD) project. The microscope will be designed to sit on the...
Light-Activated Gene Expression Could Uncover Cancer Therapies
KYOTO, Japan, July 25, 2017 — In a novel approach to light-inducible gene regulation, researchers began by modifying the surface of nanorods to make them more efficient in transporting cancer-killing genes to cells. The gold nanorods, which produce heat when exposed to a NIR...
Raman-Based Approach Images Biological Processes in Action
MARSEILLE, France, July 14, 2017 — A fast, novel imaging technique could improve molecular-scale understanding of the biological processes involved in the early stages of disease. The technique uses polarization-resolved coherent Raman scattering (polar-CRS) to reveal a...
Ultrafast Optics Faces Challenges Outside of Research Labs
Jul 10, 2017 — Ultrafast optics is currently a scientifically dominated area with a lot of dynamics in both research and development. Often, complex setups make it challenging to create compact devices that can be employed for applications outside of the...
Optogenetic Tool Efficiently Manipulates Protein Clusters
DAEJEON, South Korea, June 28, 2017 — An optogenetic technique dubbed CRY2clust is able to trigger protein cluster formation in response to blue light at a faster and more efficient rate than existing methods. CRY2clust is based on a photoreceptor protein called cryptochrome 2 (CRY2),...
Probe Delivering Optoelectronic Stimulation May Strengthen Understanding of Spinal Cord
CAMBRIDGE, Mass., May 10, 2017 — A rubber-like fiber that can flex and stretch with the human spine while delivering both optical impulses and electrical connections for stimulation and monitoring of the spine could be used in the study of spinal cord neurons and potentially to...
Path Opens for Optogenetic Tools Regulated by Red Light
GRAZ, Austria, March 23, 2017 — The observation of sensor-effector coupling in the full-length structure of a protein responsive to red light could aid in the development of red-light regulated optogenetic tools for targeted cell stimulation. Light-regulated enzymes have potential...
Optogenetics Platform Uses Light to Activate Control of Intracellular Phase Transitions
PRINCETON, N.J., Jan. 6, 2017 — A novel optogenetics platform, dubbed optoDroplet, uses light to activate phase transitions inside living cells. The optoDroplet system is being used to study the condensed phases driven by intrinsically disordered protein regions (IDRs). Its use...
Light Therapy Shown to Reduce Plaques in Mice with Alzheimer’s
CAMBRIDGE, Mass., Dec. 21, 2016 — Using LEDs that can be programmed to flicker at different frequencies on mouse models genetically programmed to develop Alzheimer’s, researchers are exploring the potential of using light to reduce amyloid-β (Aβ) plaque levels and to...
Optical Probe Overcomes Light Scattering in Deep-Brain Imaging
PASADENA, Calif., Dec. 12, 2016 — An implantable, ultra-narrow photonic probe has been developed which is able to deliver light deep within brain tissues. Current methods, which project spatially patterned light via free-space optics, excite neurons within superficial layers of the...
New Treatment for Inflammatory Disease Uses Optogenetic Tool
ITHACA, New York, Dec. 9, 2016 — An optogenetic approach to regulating inflammation and immunity in the human body employs photocontrolled inhibitors that are selectively delivered to the target cells via UV radiation. This novel approach could further the study of inflammation and...
Optical Imaging Platform Uses Light to Treat Arrhythmia
SESTO FIORENTINO and FLORENCE, Italy, Nov. 28, 2016 — Use of light to defibrillate cardioarrhythmic events in humans could offer a gentler alternative to shocking the heart back to normal rhythm through a generalized electrical discharge. With the introduction of Channelrhodopsin (ChR) as a tool to...
Open Source Platform May Reduce Entry Barrier to Optogenetics Testing
HOUSTON, Nov. 11, 2016 — An optogenetics platform has been developed using open-source hardware and software. The platform is available for biologists who want to incorporate optogenetics testing in their own labs and may reduce the entry barrier to optogenetics and...
NIH Awards $1.4M Grant to Support Optogenetics Research
JUPITER, Fla., Oct. 19, 2016 — A $1.4 million, three-year grant from the National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH) has been awarded to Dr. Ryohei Yasuda, scientific director at the Max Planck Florida Institute for Neuroscience (MPFI)...
Protocols Introduced for Graphene-Based Array for Biophotonics Applications
MADISON, Wis., Oct. 17, 2016 — The fabrication and use of transparent graphene-based neural electrode arrays for applications in fluorescent microscopy, OCT and optogenetics have been described in detail by the researchers who developed the array. The arrays could provide...
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