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pharmaceutical News
Ultrasensitive Chirality Detector Could Improve Drug Design and Efficacy
ORLANDO, Fla., April 1, 2024 — Researchers at the University of Central Florida (UCF) are investigating ways to enhance the development of new drugs and therapies. A tunable plasmonic platform from UCF, which enables accurate detection of chiral molecules, could help pharmaceutical companies and biomedical labs classify enantiomers with speed and precision, leading to more efficient drug development. The platform for sensing chiral molecules is the work of a team led by professor Debashis Chanda at the UCF Nanoscience
AI and Laser Tech Automate Rapid Sorting and Analysis of Live Cells
AACHEN, Germany, March 25, 2024 — To realize the potential of personalized medicine and overcome crisis situations like the recent pandemic, labs need an efficient way to isolate living cells for analysis and testing. The ability to isolate specific cell types without impairing cell...
DMD-Based SIM Attains Fast Superresolution Bioimaging in 3D
BEIJING, March 4, 2024 — Although structured illumination microscopy (SIM) demonstrates ultrahigh temporal and spatial resolution, the speed and intricacy of polarization modulation affect the speed and quality of its imaging resolution in 3D. A 3DSIM technique, developed...
High-Throughput Imaging Reveals Multi-Particle Cellular Activity
BONN, Germany, Feb. 5, 2024 — A new software program can map the movements of multiple particles within cells simultaneously, providing insight into cellular functions that are difficult — and sometimes impossible — to investigate using single-cell tracking methods....
Machine Learning Hones Ability to Image Liver Disease
TOKYO, Jan. 29, 2024 — A research team at the Tokyo University of Science (TUS) has combined NIR hyperspectral imaging (NIR-HSI) and machine learning to assess lipid content in the liver. The technique enables noninvasive diagnosis of steatotic liver disease (SLD),...
Multispectral Terahertz Imaging System Incorporates Neural Network
LOS ANGELES, Jan. 29, 2024 — Researchers at UCLA have developed a focal plane array (FPA) capable of supporting real-time multispectral terahertz (THz) video in 3D. According to the team, led by UCLA professors Mona Jarrahi and Aydogan Ozcan, this is the first time a terahertz...
Photodynamic Method Boosts Antibiotics Against Drug-Resistant Bacteria
SÃO CARLOS, Brazil, Jan. 8, 2024 — Multidrug-resistant bacteria are considered a serious threat to infection control. Faced with the increasing difficulty of developing new antibiotics to combat resilient bacterial strains, scientists are turning to photodynamic inactivation (PDI), a...
Flow Cytometry Uncovers Predictive Biomarker for Severe COVID
MUNICH, Dec. 19, 2023 — Using image-based flow cytometry, researchers at the Technical University of Munich (TUM) identified a biomarker for predicting how serious a COVID-19 infection will be. They also developed a rapid test for assessing a patient’s risk of severe...
Algorithm Boosts Live-Cell Imaging's Capabilities
OEIRAS, Portugal, Nov. 27, 2023 — Superresolution radial fluctuations (SRRF), a superresolution algorithm, works by observing fluctuations in radial symmetry throughout the frames of an image. SRRF supports live-cell, superresolution microscopy on a range of microscopy platforms...
Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport
DAEJEON, South Korea, Nov. 22, 2023 — Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of photobleaching and the visual isolation of cellular...
Light-Activated Tool Controls Protein Bonds and Tracks Cell Adhesion
TAMPERE, Finland, Nov. 20, 2023 — Optical tools can be used to activate biological functions, but with current methods the effects are slow to appear, and sustained effects require continuous light activation. As a result, these light-activation tools provide limited control of fast...
Algorithm Targets Microscope Resolution
BOSTON, Nov. 16, 2023 — Scientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the microscope’s point spread function, is one approach....
Low-Power Optical Tweezers Protect Bioparticles from Damage
AUSTIN, Texas, Nov. 10, 2023 — Optical tweezers trap and manipulate minute particles with light. The technology is used across fields, ranging from manufacturing to biotech, though it requires the use of high-powered lasers to ensure proper function. These lasers can damage the...
Lasers Improve Phototherapy-Drug Delivery Platform
BALTIMORE, Nov. 7, 2023 — Photoimmunotherapy targets cancer cells with microscopic, nano-engineered cancer drugs that are light-activated at the lesion site. Although the technology is increasingly used to treat metastatic cancer, tools to improve the effectiveness of...
Compact Quasiparticle Light Source Could Rival FELs' Brightness
ROCHESTER, N.Y., Oct. 24, 2023 — An international team of scientists is rethinking the principles of radiation physics, with the goal of creating super-bright light sources that are compact and relatively convenient to use. Coherent light sources such as free-electron lasers (FELs)...
Microscopy Method Detects Treatment-Resistant Cancer
BALTIMORE, Oct. 9, 2023 — Therapy-induced senescent (TIS) cells are cancer cells that become resistant to therapies and enter a dormant stage. These cells can emerge from dormancy and induce tumor resistance and relapse. To provide insight into how TIS cells evolve, it is...
Wearable Sensor Could Detect Postpartum Blood Loss
WASHINGTON, D.C., Oct. 3, 2023 — Postpartum hemorrhage, the leading and most preventable cause of maternal mortality, can be hard to detect, because physiological compensation mechanisms can mask excessive bleeding. In the early stages of hemorrhage, the sympathetic nervous system...
Single-Cell Analysis Optofluidics Tool Delivers on Demand
QINGDAO, China, Sept. 20, 2023 — An on-demand optical system for exporting target droplets from a static droplet array (SDA) provides a simple way to export specific cells or analytes for analysis without compromising efficiency or accuracy. Researchers at the Qingdao Institute of...
Photoacoustic Microscopy Method Delivers Higher Sensitivity
HONG KONG, Sept. 15, 2023 — A multispectral, super-low-dose photoacoustic microscopy (SLD-PAM) system developed by City University of Hong Kong (CUHK) achieves significantly higher sensitivity than traditional optical resolution photoacoustic imaging. By providing an...
Tomography Techniques Recover Scattered Light to Speed 3D Imaging
WASHINGTON, D.C., Aug. 24, 2023 — Although 3D imaging techniques are useful for studying thick biological samples, the challenge to achieve both high-speed acquisition and high resolution of 3D images persists. Intensity diffraction tomography (IDT), a label-free phase tomography...
Light-Activated Metal Particles Deliver Targeted Cancer Treatment
NOMI, Japan, Aug. 15, 2023 — A research group from Japan Advanced Institute of Science and Technology (JAIST) developed light-activatable, liquid metal (LM) nanoparticles for cancer diagnosis and treatment via photoimmunotherapy. The LM nanoparticles can target and destroy...
Near-IR Biosensors Use DNA Anchors to Target Range of Molecules
BOCHUM, Germany, Aug. 10, 2023 — To build a flexible sensor for optically detecting a range of viruses and bacteria, a group of researchers from Ruhr University Bochum (RUB), the Fraunhofer Institute for Microelectronic Circuits and Systems (IMS), and ETH Zurich used...
Microscopy Method Uses Infrared Light to Image Molecules with Vibrational Contrast
PASADENA, Calif., July 7, 2023 — The complementary strengths of fluorescence and vibrational microscopy are combined in a new technique developed at Caltech, which is called bond-selective fluorescence-detected infrared-excited spectro-microscopy (BonFIRE). BonFIRE will benefit...
Time-Resolved Spectroscopy Peers in on Irreversible Phenomena
OTTAWA, Ontario, June 26, 2023 — A team of researchers at the University of Ottawa developed a terahertz (THz) spectroscopy technique for recording movies in real time at 50,000 fps. High-speed video captures and slow-motion movies allow scientists to observe the mechanical...
Thermo Fisher Acquires Raman Specialists MarqMetrix
WALTHAM, Mass., June 22, 2023 — Thermo Fisher Scientific has acquired MarqMetrix, a privately held developer of Raman-based spectroscopy solutions for in-line measurement. Based in Seattle, MarqMetrix provides in-line process analytical technology (PAT) for precise measurements...
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April 2024
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