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superresolution News
DMD-Based SIM Attains Fast Superresolution Bioimaging in 3D
BEIJING, March 4, 2024 — Although structured illumination microscopy (SIM) demonstrates ultrahigh temporal and spatial resolution, the speed and intricacy of polarization modulation affect the speed and quality of its imaging resolution in 3D. A 3DSIM technique, developed by a team led by professor Peng Xi at Peking University, leverages digital display technology to achieve a rapid, reliable, multidimensional SIM imaging tool for investigating diverse biological phenomena. The new microscopy technique blends 3D
SPAD Elevates Spatiotemporal Resolution in Conventional Microscopes
GENOA, Italy, Feb. 23, 2024 — Image scanning microscopy (ISM), a superresolution technique enabled by the advent of fast and compact detector arrays, provides better signal-to-noise ratio (SNR), optical sectioning, and spatial resolution better than that of a traditional...
Algorithm Boosts Live-Cell Imaging's Capabilities
OEIRAS, Portugal, Nov. 27, 2023 — Superresolution radial fluctuations (SRRF), a superresolution algorithm, works by observing fluctuations in radial symmetry throughout the frames of an image. SRRF supports live-cell, superresolution microscopy on a range of microscopy platforms...
Label-Free Imaging Shows Dynamics of Intracellular Cargo Transport
DAEJEON, South Korea, Nov. 22, 2023 — Until now, scientists have relied on fluorescence microscopy techniques to study intracellular cargo transport, a vital process to maintaining essential cellular functions. However, the effects of photobleaching and the visual isolation of cellular...
Algorithm Targets Microscope Resolution
BOSTON, Nov. 16, 2023 — Scientists have used various approaches to improve spatial resolution in fluorescence microscopy. Deconvolution, in which images are numerically deblurred based on a knowledge of the microscope’s point spread function, is one approach....
Virtual Superlens Passes Diffraction Limit Without Distortion
SYDNEY, Nov. 6, 2023 — The diffraction limit enforces physical restrictions on how closely an object can be examined using traditional optical methods. Previous attempts to develop superlenses that image beyond the diffraction limit have met with extreme visual losses, to...
Brain Imaging, Image Reconstruction Combine in a Single Workflow
KLOSTERNEUBURG, Austria, July 18, 2023 — Scientists at Institute of Science and Technology Austria (ISTA) have developed an imaging technology to analyze live brain tissue at a scope and spatial resolution that, according to the researchers, was not previously possible. The technology,...
DNA-Barcoded Fluorescence Imaging Illuminates Core Cell Components
MUNICH, June 13, 2023 — Since many core components of cells — like DNA, RNA, proteins, and lipids — are just a few nanometers in size and substantially smaller than the resolution limit of traditional light microscopy, the exact composition and arrangement of...
Graphene Properties Add Axial Resolution Precision to 3D Imaging
MUNICH, March 14, 2023 — Researchers at the Ludwig Maximilian University of Munich (LMU) combined pulsed-interleaved MINFLUX (pMINFLUX) nanoscopy with a newly developed method for axial resolution that exploits the special properties of the 2D material graphene to achieve...
Multimodal Microscopy Provides Window into Viruses’ Beginnings
DURHAM, N.C., Nov. 23, 2022 — To better understand how viruses breach the protective layers of cells that line the airways and gut, Duke University researchers used multimodal microscopy to capture real-time video footage of viruses as they approach their cellular targets. Using...
Superresolution Method Could Improve Understanding of Gene Function
BARCELONA, Oct. 18, 2022 — An interdisciplinary team from the Centre for Genomic Regulation (CRG) and the Institute for Research in Biomedicine (IRB Barcelona) has developed an imaging technique that captures the structure of the human genome to reveal how individual genes...
Microscopy Methods Pair to Advance Nanoscale Superresolution Imaging
PITTSBURGH, May 24, 2022 — Researchers combined stimulated Raman scattering (SRS) with expansion microscopy to develop a single microscopy technique that achieves superresolution vibrational imaging at the nanoscale. A team from Carnegie Mellon and Columbia universities...
Noninvasive Imaging Method Measures Below the Diffraction Limit
WASHINGTON, D.C., April 29, 2022 — A label-free microscopy technique developed by researchers at the University of Graz enables noninvasive, sub-diffraction-limit imaging of nanostructures. The all-linear, optical far-field measurement and imaging technique measures the position and...
Rotating Laser Enables Faster, Longer Imaging of Cells
FREIBURG, Germany, April 20, 2022 — A microscopy method developed at the University of Freiburg is able to resolve cellular-level detail without fluorescence, enabling observations 100 to 1000× longer and 10 to 100× times faster, with almost double the resolution. The...
Eikon Therapeutics Raises $518M, Completes Recruitment of Leadership Team
HAYWARD, Calif., Jan. 10, 2022 — Eikon Therapeutics, a company focused on the application of superresolution microscopy to drug discovery, closed a $517.8 million Series B financing round. Since its founding, Eikon Therapeutics has raised more than $688 million. The company has...
Metamaterial Lets Light-Sheet Microscopes See in Superresolution
SAN DIEGO, June 4, 2021 — A hyperbolic metamaterial developed at the University of California, San Diego enables ordinary light-sheet microscopes to observe subcellular structures — in other words, enabling an ordinary light microscope to see in superresolution. The...
Microscopy Method Resolves Fluorescence at Nanometer Scale
GÖTTINGEN, Germany, March 24, 2021 — Researchers led by Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry and the Heidelberg-based MPI for Medical Research have developed a light microscopy method, MINSTED, that is able to resolve fluorescently labeled details...
Microscope Technology Based on NanoLED Array Platform Moves Toward Commercialization
BARCELONA, Spain, March 16, 2021 — An international team led by researchers at the University of Barcelona developed a superresolution optical chip-size microscope that is supported by nanoLEDs functioning as a light source. The nanoLEDs can determine the resolution of the microscope...
Multimodal Imaging Could Detect Cancerous Cells Faster, More Accurately
HANNOVER, Germany, Jan. 4, 2021 — A European research project called CARMEN seeks to improve the detection of cancerous cells during surgery through the use of multimodal imaging. The project is led by Laser Zentrum Hannover (LZH) and Multitel asbl in Belgium, with support from...
Superresolution on the SPOT: Imaging Achieves Optical Sectioning
SYDNEY, Nov. 19, 2020 — A technique called SPOT (spectrum and polarization optical tomography) is providing researchers with a “street view” of lipid membranes surrounding cell organelles, thereby allowing insight into lipid dynamics. The work is the result of...
International Team Awarded $13M Grant for Superresolution Microscopy
WÜRZBURG, Germany, Nov. 11, 2020 — An international research team headed by Markus Sauer of the University of Würzburg has been awarded a grant to pursue research in superesolution microscopy, aimed at advancing the study of proteins as they relate to the function of the nervous...
Image Scanning Microscopy Technique Extends Beyond Limits
WARSAW, Poland, Oct. 22, 2020 — A collaboration between researchers at the University of Warsaw and the Weizmann Institute of Science yielded a method of fluorescence microscopy that, in theory, has no resolution limit. In practice, the team demonstrated a fourfold improvement...
Superresolution Microscopy Analysis Accelerated by Machine Learning
Sep 4, 2020 — Superresolution optical microscopy — a technology that enables the acquisition of fluorescent micrographs of samples with a resolution well below the optical diffraction limit of ~250 nm — is rapidly evolving. Several methods have been developed...
Display Resolution Increases by 3D-Printing Quantum Dot Nanopixels
CHANGWON, South Korea, Aug. 19, 2020 — A display technology developed at the Korea Electrotechnology Research Institute (KERI) produces 3D pixels with nanoscale dimensions by 3D-printing quantum dots (QDs) embedded in polymer nanowires. The technology — called “nanophotonic...
Photonic Instruments, Components Driving (and Steering) NASA’s Mars Rover
Aug 19, 2020 — Numerous photonic devices and applications are contributing to the pursuit of microbial life on Mars, or, more accurately, the quest to determine if, among other novel possibilities, such lifeforms once inhabited the Red Planet. Among the hundreds...
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April 2024
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