SERS-Based Biophotonics: From Nanotags to Point-of-Care Testing

Oct 25, 2023
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About This Webinar
Today, surface-enhanced Raman scattering (SERS) is widely used in the chemical, life, and material sciences. This presentation begins with a short tutorial on the fundamentals of SERS.

Schlücker then discusses recent results on experimental precision plasmonics for applications in biomedical imaging and chemical energy conversion using molecularly functionalized noble metal colloids in conjunction with SERS. First, he presents a highly efficient synthesis of SERS labels and nanotags, which generates extremely bright dimer particles in very high yield with precise distance control at the level of single chemical bonds.

Correlative microscopic and microspectroscopic experiments at the single-particle level demonstrate their unprecedented optical properties. Secondly, he addresses applications of immune-SERS (iSERS) using SERS nanotag-labeled antibodies, including a rapid, quantitative, and ultrasensitive SERS-based lateral flow assay with a home-built compact Raman reader as well as iSERS microscopy for single cell- and tissue-based cancer diagnostics.

*** This presentation premiered during the 2023 BioPhotonics Conference. For more information on Photonics Media conferences and summits, visit

About the presenter

Sebastian SchlückerSebastian Schlücker, Ph.D., is a professor of physical chemistry at the University Duisburg-Essen (UDE) in Essen, Germany. He studied chemistry at the University of Würzburg where he also obtained his doctorate in the field of linear and nonlinear Raman spectroscopy. After postdoctoral work at the laboratory of chemical physics, NIDDK, NIH in Bethesda, Maryland, on Raman imaging in biomedical research and his habilitation he became associate professor of experimental physics at the University of Osnabrück in 2008 before joining UDE in 2012. His research interests include the development and application of innovative laser spectroscopic techniques with a focus on selectivity and sensitivity as well as the physics and chemistry of molecularly functionalized plasmonic nanoparticles for applications in biomedicine and chemical energy conversion.

Schlücker received numerous awards for his scientific work such as those from the German Chemical Society (GDCh) including the Carl-Duisberg Memorial Award, the Bunsen-Kirchhoff Award, and an ADUC Award. Last year, he received the ICORS 2022 Award for the most innovative technological development.

He serves as deputy director of the Center for Nanointegration Duisburg-Essen (CENIDE) and as a member of the International Steering Committees of the International Conference on Raman Spectroscopy (ICORS) and the International Conference on Enhanced Spectroscopies (ICES). In 2018 he was elected as a Fellow of the Royal Society of Chemistry (FRSC). He is the founder of NanoWerke which works on high-quality SERS particles, and he initiated experimentamus! which provides inquiry-based learning with STEM experiments in primary schools.
spectroscopyBiophotonicsSERScancer diagnostics
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