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Self-Assembled Porphyrin Nanoparticles for Biophotonic Imaging and Light-Controlled Drug Delivery

Jun 18, 2015
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Porphyrins have played numerous historic roles in the diagnosis and treatment of diseases, in particular based on how these molecules interact with light. Some recent approaches that form new nanostructured materials from porphyrins and related molecules have potentially enabling properties for disease diagnosis and therapy.
This talk will address two recently reported nanoscale systems, both involving high-density porphyrin constructs. First, porphyrin nanovesicles have been developed that can release drugs in response to near-infrared (NIR) laser irradiation, leading to enhanced drug deposition in irradiated tumors. Second, a family of highly light-absorbing nanoparticles have been developed for safe and real-time gastrointestinal photoacoustic imaging following oral administration to mice.

Presenter Jonathan F. Lovell is an assistant professor of biomedical engineering at the State University of New York at Buffalo. He received his doctorate in biomedical engineering from the University of Toronto in 2012.

Lovell is an elected councilor for the American Society of Photobiology. He was a 2013 recipient of the National Institutes of Health Early Independence Award. His works have appeared in Nature Communications, Nature Nanotechnology, Nature Materials, Nature Chemistry and Cell. His main focus is on developing translatable nanoplatforms with applications in photomedicine and theranostic imaging.

NIRporphyrinsphotoacoustic imagingimagingbiophotonic imagingnanoparticlesdrug deliveryBiophotonicsmaterials
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