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The Low-Noise Revolution Changes the Game … Again

Jan 22, 2021
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ABOUT THIS WEBINAR
Discovery in the life sciences is moving at warp speed. Born from the fusion of advancements in fluorescent probe chemistry, tissue clearing, genetic engineering, optics, computational imaging, and detector technology, investigators are imaging living cells with greater speed, longer duration, wider fields of view, increased tissue depth, and higher spatial and temporal resolution. As a result, it is now possible to see the inner workings of living cells, view in real-time the development of an embryo, or tour the 3D connectome of whole cleared brains.

In this presentation, Brad Coyle and colleagues explore the developments in camera technology, specifically scientific CMOS (sCMOS) cameras, that enable these new imaging applications and how sCMOS compares to older technologies such as CCDs and EMCCDs (electron multiplying CCDs). At the surface, it would seem that cameras simply need to go faster or have more "sensitivity." But it is truly the combination of high speed, high quantum efficiency (QE), high uniformity, plus low read noise that makes such advancements possible. With low read noise as the anchor, these features coalesce to give the ultimate camera performance and produce images with high signal to noise ratio, even in photon-starved conditions. Images that are innately quiet provide the best data for quantitative and computational imaging techniques and pave the way for successful implementation of AI.

***This presentation premiered during the 2021 Photonics Spectra Conference Biomedical track. For information on upcoming Photonics Media events, see our event calendar here.

About the presenter:
Brad Coyle Brad Coyle has been working in imaging for over 15 years. His career began out of graduate school working in advanced microscopy sales. He joined Hamamatsu six years ago, beginning with camera technology sales, and quickly moved into OEM and automated imaging. His expertise includes camera and sensor technology, and advanced applications. Hamamatsu focuses on light-powered innovation, with a mission is to benefit society through the development of technologies that capture, measure, and generate various types of light.
biomedical imaginglife sciencesscientific CMOS camerassCMOS
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