Search Menu
Photonics Media Photonics Buyers' Guide Photonics EDU Photonics Spectra BioPhotonics EuroPhotonics Industrial Photonics Photonics Showcase Photonics ProdSpec Photonics Handbook
More News
Email Facebook Twitter Google+ LinkedIn Comments

Imaging agent may reveal which tremors are caused by Parkinson’s disease

Dec 2006
Approximately 1.5 million people in the US have Parkinson’s disease, and as many as 10 million others are afflicted by essential tremor, a condition that often is confused with Parkinson’s. According to a 2002 report in the European Journal of Neurology, there is a 20 to 30 percent misdiagnosis rate in the early stages of Parkinson’s disease. Now Dr. Mark Pykett and his colleagues at Boston Life Sciences Inc. in Hopkinton, Mass., have tested whether the company’s molecular imaging agent, Altropane, can distinguish between tremors caused by Parkinsonian syndrome and those associated with other disorders more accurately than clinical diagnoses from physicians.

The imaging agent binds to the dopamine transporter protein found on the surface of dopamine-producing neurons, making it visible during single-photon emission computed tomography. Because most Parkinsonian syndromes usually result in a decreased number of dopamine-producing cells, the researchers believed that patients with these syndromes also would have fewer dopamine transporter proteins. Therefore, they hypothesized that the agent would enable them to see whether tremors are associated with Parkinsonian diseases or with the other disorders.

A primary care physician first evaluated patients with tremors and judged whether the tremors were related to Parkinson’s disease. The patients then underwent scans — utilizing the imaging agent — and these scans were evaluated by imaging experts who were blind to the patients’ clinical data. Finally, a movement disorder specialist — whose diagnosis was considered the gold standard for the study — determined which of the patients had Parkinson’s disease. The scans showed statistically significant superiority over the nonspecialist physicians’ clinical evaluations in distinguishing the cause of tremors.

The researchers believe that the imaging agent will enable physicians to provide more informed prognoses for their patients earlier as well as to prescribe effective treatments.

BiophotonicsFrom The Clinic

Terms & Conditions Privacy Policy About Us Contact Us
back to top
Facebook Twitter Instagram LinkedIn YouTube RSS
©2019 Photonics Media, 100 West St., Pittsfield, MA, 01201 USA,

Photonics Media, Laurin Publishing
x Subscribe to BioPhotonics magazine - FREE!
We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.