Drug discovery, HTS
Issue 16 of “Cell Notes,” a serial
publication of Promega Corp., focuses on drug discovery and high-throughput screening,
emphasizing the use of in vitro assays to understand in vivo biology. The 32-page
document includes articles on the MultiTox-Fluor multiplex cytotoxicity assay, and
on in vitro compound profiling in 384- and 1536-well plates using bioluminescent
assay systems. It discusses multiplexed viability, cytotoxicity and apoptosis
assays for cell-based screening, and the DPPIV-Glo luminescent protease assay, which
detects Gly-Pro cleaving activity in serum. Sections also cover timing apoptosis
assays and the use of luciferase reporter assays to screen for G-protein-coupled
receptor modulators. A kinase assay product flowchart is included.
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