Search Menu
Photonics Media Photonics Buyers' Guide Photonics EDU Photonics Spectra BioPhotonics EuroPhotonics Industrial Photonics Photonics Showcase Photonics ProdSpec Photonics Handbook
More News
Email Facebook Twitter Google+ LinkedIn Comments

UV light helps skin cancer cells thrive

Feb 2011
By activating the enzyme protein kinase D, ultraviolet light helps nonmelanoma skin cancer cells survive and proliferate, researchers have found.

The new research demonstrates that the effects of UV are cumulative and also dose-dependent, which means that more exposure to ultraviolet light leads to more protein kinase D activity.

The enzyme isn’t all bad. Normally, protein kinase D helps regulate the replacement of cells that are continuously sloughed off. It enables skin cells to survive constant exposure to UV light.

Dr. Wendy Bollag and Dr. Ismail Kaddour-Djebbar, a postdoctoral fellow and study co-author, have provided insight into how ultraviolet light causes nonmelanoma skin cancers, pointing the way toward better treatment. Courtesy of Phil Jones, MCG.

But because it promotes cell survival, it can make badly damaged skin cells more likely to turn cancerous because it reduces their natural self-destruct ability, the researchers have shown.

The team previously discovered that protein kinase D was upregulated in basal cell carcinoma. Sun exposure has been established as the most significant risk factor for basal cell carcinoma, so the researchers suspected that there was a link between ultraviolet radiation and protein kinase D.

Pretreating skin cells with antioxidants, they now have found, appears to reduce protein kinase D activation by ultraviolet light; this could mean that free radicals also play a role.

The research took place at the Medical College of Georgia and the Charlie Norwood Veterans Affairs Medical Center. The study was published in the journal Oncogene.

Americasantioxidantsbasal cell carcinomaBiophotonicsBioScanCharlie Norwood Veterans Affairs Medical CenterIsmail Kaddour-Djebbarkinase DMedical College of GeorgiaNewsnon-melanomaOncogeneskin cancersun exposureultravioletultraviolet radiationUV lightWendy Bollag

Terms & Conditions Privacy Policy About Us Contact Us
back to top
Facebook Twitter Instagram LinkedIn YouTube RSS
©2018 Photonics Media, 100 West St., Pittsfield, MA, 01201 USA,

Photonics Media, Laurin Publishing
x Subscribe to BioPhotonics magazine - FREE!
We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.