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Zeiss Microscopy technology granted European patent

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Drs. Harald Hess and Eric Betzig of Carl Zeiss Microscopy have received a European patent for their superresolution photoactivated localization microscopy (PAL-M) technology. They received US patents based on the same invention in 2009 and 2011.

The latest patent protects methods and devices for PAL-M, which activates and excites only a small number of fluorescent dye molecules in a sample at a time. This enables the physical position of the individual fluorescent molecules to be determined to within a few nanometers. A superresolution image of the sample is generated by repeating a photoinduced separation of fluorescent dye molecules and adding consecutively captured individual images.

Carl Zeiss Microscopy obtained exclusive rights to place PAL-M on the market in 2007, and on this basis, developed the ELYRA P.1 and PS.1 superresolution systems.
PI Physik Instrumente - Revolution In Photonics Align ROS MR 3/24

Published: June 2013
Glossary
superresolution
Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
BiophotonicsCarl Zeiss MicrosocpyELYRA P.1 and PS.1Eric BetzigEuro NewsEuropeEuropean patentGermanyHarald HessImagingMicroscopyNewsPAL-MPatent EP 1894010 B1superresolutionsuperresolution imagingUS patents

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