Search Menu
Photonics Media Photonics Buyers' Guide Photonics EDU Photonics Spectra BioPhotonics EuroPhotonics Industrial Photonics Photonics Showcase Photonics ProdSpec Photonics Handbook
More News
Email Facebook Twitter Google+ LinkedIn Comments

Computer Model Details QD Interaction with Protein
Jan 2015
SYRACUSE, N.Y., Jan. 16, 2015 — A new computer modeling approach could increase understanding of how nanoscale quantum dots (QDs) interact with biological systems.

QDs are used in a number of bioimaging applications, including in vivo imaging of tumor cells, detection of biomolecules and measurement of pH changes. But proteins tend to surround the nanoparticles, forming a corona that changes their sensitivity to light.

Protein corona around a CdSe QD.
A model of a firefly luciferase protein corona around a CdSe quantum dot. Courtesy of Drs. Shikha Nangia and Arindam Chakraborty/ Syracuse University.

Researchers at Syracuse University said they have addressed a “computational bottleneck” that limited theoretical study of protein coronas. Their method combines pseudopotential and explicitly correlated Hartree-Fock quantum mechanical calculations with classical molecular mechanics and dynamics, as well as Monte Carlo techniques.

The team modeled the formation of a corona around a 5 nm cadmium selenide QD, finding that it produced an 8-nm red shift. They said the technique can be applied to bigger and more complex QD systems.

The research was published in the Journal of Chemical Theory and Computation (doi: 10.1021/ct500681m).

For more information, visit

Research & TechnologyAmericasNew YorkSyracuse Universityquantum dotQDimagingBiophotonics

Terms & Conditions Privacy Policy About Us Contact Us
back to top

Facebook Twitter Instagram LinkedIn YouTube RSS
©2018 Photonics Media, 100 West St., Pittsfield, MA, 01201 USA,
x We deliver – right to your inbox. Subscribe FREE to our newsletters.