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Three-dimensional virus image captured with 4.5-Å resolution

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Single-particle electron cryomicroscopy recently helped a group of researchers to capture a 4.5-Å-resolution 3-D image of the capsid of ε15, a double-stranded DNA bacteriophage — a virus that infects bacteria. Wen Jiang from Purdue University in West Lafayette, Ind., and Matthew L. Baker from Baylor College of Medicine in Houston, led the group, which also included members from MIT in Cambridge, Mass. The image of the 22-MDa structure provided enough details to trace the polypeptide chain (see figure). This information could reveal how the proteins in the capsid perform biological...Read full article

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    Published: April 2008
    3-D ImageAs We Go To PressBiophotonicsBreaking NewsDNA bacteriophageMicroscopyPresstime BulletinSingle-particle electron cryomicroscopy

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