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Measuring viscosity with fluorescence lifetime imaging

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Technique allows imaging of heterogeneous samples with high spatial resolution.

Gary Boas

A number of diseases and malfunctions at the cellular level can be attributed, at least in part, to changes in viscosity —one of the primary determinants of the diffusion rate in condensed media — which is integral to metabolic processes, signaling and transport. A number of studies have reported methods for measuring bulk macroscopic viscosity. However, because they typically require large sample volumes, these methods “are not suitable for mapping viscosity in heterogeneous samples,” said Marina K. Kuimova, a researcher with Imperial College London. “Working with biological samples, such as...Read full article

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    Published: July 2008
    Biophotonicscellular leveldiseasesenergyMicroscopyResearch & TechnologySensors & Detectorsviscosity

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