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Maldi mass spectrometry without the matrix

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Matrix-assisted laser desorption ionization (Maldi) is a widely used method for ionizing molecules before they go through the mass spectrometer. However, the use of a matrix limits the method in several ways. Because of these limitations, laser desorption ionization techniques that do not require a matrix have been developed. Dominic S. Peterson of Los Alamos National Laboratory in New Mexico has reviewed these matrix-free methods. Matrix-assisted methods use a laser to energize the matrix, which then transfers its energy to ionize the molecules in the sample. In contrast, matrix-free...Read full article

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    Published: April 2007
    Glossary
    mass spectrometer
    A device used to measure the masses and relative concentrations of atoms and molecules. It utilizes the Lorentz force generated by external magnetic field on a moving charged particle, in which the particles are deflected by the magnetic field according to their masses. Once deflected, the particles are detected and recorded electrically to provide a mass spectrum of the input beam of ions.
    BiophotonicschemicalsFrom The Journalsionizing moleculesMaldi mass spectrometrymass spectrometerspectroscopy

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