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Altered Heart Cells Controlled with Light

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BONN, Germany, Oct. 13, 2010 — Using a method called photostimulation, scientists at the University of Bonn have altered cardiac muscle cells to make them controllable with light. They were able to use directed blue light to cause conditions such as arrhythmia in genetically modified mice. Tobias Brügmann and his colleagues from the University of Bonn’s Institute of Physiology I used a so-called “channelrhodopsin” for their experiments, which is a type of light sensor. At the same time, it can act as an ion channel in the cell membrane. When stimulated with blue light, this channel opens, and...Read full article

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    Published: October 2010
    Glossary
    light
    Electromagnetic radiation detectable by the eye, ranging in wavelength from about 400 to 750 nm. In photonic applications light can be considered to cover the nonvisible portion of the spectrum which includes the ultraviolet and the infrared.
    arrhythmiaatriumBernd FleischmannBiophotonicsblue lightcardiac muscle cellscell membranechannelrhodopsinelectric stimulationEuropeGermanyheart attackheart cellsImagingion channellightlight sensorLight SourcespacemakerPhilipp SassephotostimulationResearch & TechnologySensors & DetectorsTobias BrügmannUniversity of Bonnventricleventricular fibrillation

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