Search
Menu
Zurich Instruments AG - Boost Your Optics 1-24 LB

Tip-Enhanced Raman Spectroscopy Takes Bio Fingerprinting to Nanoscale Level

Facebook X LinkedIn Email
Enabling label-free detection of surface components in multicomponent samples with ultrahigh spatial resolution, tip-enhanced Raman spectroscopy makes it suitable for studying self-assembled monolayers, protein and nucleic acid chain composition, and cell surface interactions.

MARUDA SHANMUGASUNDARAM AND FRAN ADAR, HORIBA INSTRUMENTS INC.

Despite being able to provide fingerprint information in biology, medicine and other fields, Raman spectroscopy suffers from a signal-to-noise ratio that is limited by the inherent weakness of Raman scattering and a spatial resolution that is diffraction-limited (~0.5λ). This weak Raman signal-to-noise ratio can be overcome by surface-enhanced Raman spectroscopy (SERS), which relies on surface plasmon oscillations of metal particles in contact with the material1. However, it is often desirable to advance spatial resolution beyond the diffraction limit into the nanoscale dimension,...Read full article

Related content from Photonics Media



    Articles


    Products


    Photonics Handbook Articles


    White Papers


    Webinars


    Photonics Dictionary Terms


    Media


    Photonics Buyers' Guide Categories


    Companies
    Published: July 2016
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    tip-enhanced raman spectroscopy
    A spectroscopic technique that combines the high chemical specificity of Raman scattering and signal sensitivity provided by surface plasmon resonance enhancement, with the nanoscale spatial resolution of scanning probe microscopy (SPM). Supported by a sharp metallized-SPM tip, tip-enhanced Raman spectroscopy (TERS) enables label-free detection of surface components in multicomponent samples with ultrahigh spatial resolution, making it suitable for studying nanomaterials.
    surface-enhanced raman spectroscopy
    Surface-enhanced Raman spectroscopy (SERS) is an analytical technique that combines the principles of Raman spectroscopy with the enhancement provided by nanostructured metallic surfaces. Raman spectroscopy is a method used to study vibrational, rotational, and other low-frequency modes in a system by measuring the inelastic scattering of monochromatic light, typically from a laser source. SERS enhances the Raman signal by many orders of magnitude, enabling the detection and identification of...
    BiophotonicsspectroscopysuperresolutionMicroscopytip-enhanced Raman spectroscopyTERSscanning probe microscopySPMsurface-enhanced Raman spectroscopySERS spectroscopyHoriba InstrumentsFeatures

    We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.