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Optical Tool Uses Fluorescence to Detect Metabolic Changes

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An optical tool that can read metabolism at subcellular resolution could be used to identify specific metabolic signatures indicative of disease. The method detects functional and structural metabolic biomarkers noninvasively using endogenous two-photon excited fluorescence (TPEF) from two coenzymes. The coenzymes, nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), are involved in a large number of metabolic pathways in every cell. Optical readouts of HL-1 cardiomyocytes in response to chemical uncoupling by carbonyl cyanide m-chlorophenylhydrazone...Read full article

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    Published: March 2018
    Glossary
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    Research & TechnologyeducationAmericasImagingmedicalcancerBiophotonicsoptical biomarkersfluorescenceBioScan

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