FRAPPA Photobleaching Module

Andor Technology

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For Live-Cell Photobleaching and Photoactivation

Andor Technology said FRAPPA, its new tool for laser microscopy, is an acronym for the techniques it supports. Fluorescence recovery after photobleach (FRAP) and photoactivation (PA) are imaging protocols in which a computer-steered laser beam is used to photobleach or photoactivate a user-defined region in a live cell specimen.

Frappa is a photobleaching module attached to Andor’s live-cell-friendly spinning disc Revolution system, the company said. It uses a dual galvanometer scan head and can be configured in line with a CSU and/or camera and operates in two modes.

Under Andor iQ software control, the user commands Frappa to bleach or activate regions of interest with user-defined times, laser lines and powers. Laser switching is tightly synchronized using the company's proprietary laser combiner multiport switch (MPS), and FRAPPA offers extremely stable focus and ideal conditions for live cell work, according to Andor.

“We are very excited to bring this new solution to market. We have come up with a very innovative tool for photobleach and photoactivation, giving users control of speed, intensity and positioning. FRAPPA includes a “point and shoot” mode of operation with unmatched speed and convenience for the study of dynamic processes in live preparations. Although this is a widely used technique, we are one of the first to integrate with a live-cell spinning disk confocal solution,” Market Development Manager Mark Browne said.

For more information, visit: www.andor.com

Andor Technology
7 Millennium Way
Springvale Business Park,
Belfast, BT12 7AL
Northern Ireland
Phone: +44 28-9023-7126
Fax: +44 28-9031-0792

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Published: October 2007