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Optical Probe

Nov 2010
LI-COR Biosciences, BiotechnologyRequest Info
Li-Cor Biosciences Inc. has added the IRDye 800CW HA optical probe to its BrightSite family of optical agents for in vivo imaging. Hyaluronic acid (HA) is an extracellular-matrix glycosaminoglycan formed from disaccharide units containing N-acetylglucosamine and glucuronic acid. The probe interacts with various cell surface receptors, binding to proteoglycans in cartilage and other tissues. It is suitable for targeting the lymphatic system or tumor cells that overexpress CD44 receptors and is catabolized by receptor-mediated endocytosis and lysosomal degradation. The probe can be used on near-IR detection systems.


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bindingBiophotonicsBreakthroughProductsBrightSitecartilageCD44 receptorcell surface receptordisaccharide unitendocytosisextracellular matrix glycosaminoglycanglucuronic acidHaHyaluronic acidimagingin vivo imaginginfraredIRDye 800CW HA optical probeLi-Cor Biosciences Inc.lymphatic systemlysosomal degradationN-acetylglucosaminenear-IR detectionoptical agentsoptical probeopticsPearl Impulsetissuestumor cell

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